Registration Dossier
Registration Dossier
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EC number: 279-632-6 | CAS number: 80939-62-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Assessment of the Toxicokinetic Behaviour
The test substance is a yellowish viscous liquid with a water solubility of approx. 0.1 g/l and a vapour pressure of 0.0005 hP at ambient temperature.
The test substance provokes no remarkable acute toxic effects on rats. In an acute oral toxicity study in rats, that yielded and LD50 value of >5000 mg/kg bw, dyspnoea, ruffled fur and curved body position were observed directly after application and lasted up to day 7 post application. For several hours or days, respectivley, sedation and diarrhoea was also observed. Due to the low water solubility of the test substance, uptake after oral ingestion might be low. However, in a dermal acute toxicity study, that yielded an LD50 value of >2000 mg/kg bw, dyspnoea, exophthalmus, ruffled fur, curved and ventral body position were also seen and in addition, slight sedation and diarrhoea was observed. From this acute dermal toxicity study, a systemic bioavailability might be assumed, due to the observed clinical signs sedation and slight diarrhoea, that are indicative for systemic availability. No study on acute inhalative toxicity is available. Since vapour pressure of the test substance is very low, inhalation of the substance might be negligible.
The irritating properties of the substance to eyes and particularly to the skin indicate a systemic availability too, because damage to the skin might enhance penetration.
The test substance does not show a mutagenic hazard in a bacterial test with and without metabolic activation. This suggests, the test substance not to undergo metabolic activation.
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