Registration Dossier
Registration Dossier
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EC number: 212-751-3 | CAS number: 866-81-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Most sensitive long-term toxicity data for two different freshwater invertebrate species are summarized in the WHO CICAD document (2006). According to these data, the effect concentrations for cobalt hydrogencitrate were calculated:
LC50(21d, mortality, Daphnia magna) = 16 µg Tricobalt dicitrate/L
LC50(21d, mortality, Daphnia magna) = 20 µg Tricobalt dicitrate/L
NOEC(28d, reproduction, Daphnia magna) = 2.0 µg Tricobalt dicitrate/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.016 mg/L
Additional information
Data on chronic single-species toxicity tests resulting in high quality NOEC/L(E)C10 values (expressed as Co) for freshwater invertebrates (n=4) are summarised in Table 2 of the WHO CICAD document, 2006 (see attached document).
Chronic data for two different species were extracted and used in the effects assessment. The 21-day LC50 values (mortality) for Daphnia magna range from 21 μg cobalt chloride hexahydrate/L (Biesinger & Christensen, 1972; key study) to 30 μg cobalt sulfate/L (Kimball, 1978), resulting in recalculated values from 16 to 20 µg Tricobalt dicitrate/L.
More sensitive values were available as 7-day, 21-day and 28-day NOECs (reproduction) for Daphnia magna (21-d and 28-d) and Ceriodaphnia dubia (7-d), and ranged from <3 to 13 (unknown cobalt compound) and 30 to 50 µg (unknown cobalt compound), with the most reliable NOEC(28d) of 3 µg cobalt sulfate/L (Kimball, 1978). The latter NOEC would result in a value of 2.0 µg Tricobalt dicitrate/L. Another NOEC(28d) on reproduction and survival of Daphnia magna resulted in values between 30 and 50 µg unknown cobalt compound/L.
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