Registration Dossier
Registration Dossier
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EC number: 800-526-8 | CAS number: 1273322-45-4
Endpoint summary
Administrative data
Description of key information
Additional information
Category Approach for Primary alkyl amines and their salts e.g. Acetates
Primary alkyl amines were already assessed for their environmental and human health hazards and risks under the EU Existing Chemicals Regulation 793/93/EEC. Industry has provided a justification for the category approach to the German rapporteur BAuA on 2001-04-07 (see attached file in IUCLID Chapter 13). This justification was accepted as basis for the EU Risk assessment and is used for the REACH registration as well.
Speciation of Primary alkyl amines
In aqueous medium the unprotonated and the protonated amine are in equilibrium. The percentage of the unprotonated and the protonated amine is determined by the acid constant pKa and the given pH. In the table the percentages are given as function of pH and the pKa of 10.5 for Primary alkyl amines.
| pH | Percentage Protonated amine (N+) | Percentage Unprotonated amine (N) |
| 9 | 97.5% | 2.5% |
| 7 | 99.975% | 0.025% |
| 4 | 99.99997% | 0.000003% |
CONCLUSION:
Under environmental conditions it is not relevant if the unprotonated or the protonated amine will be introduced in an aquatic medium. The composition of the protonated and unprotonated amine is soley determined by the pKa and the given pH (see table above). Therefore test results in aquous media from the unprotonated and protonated amine are equivalent..
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