Registration Dossier
Registration Dossier
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EC number: 256-350-1 | CAS number: 48076-38-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-Propenoic acid, C16-18-alkyl esters
- EC Number:
- 292-060-1
- EC Name:
- 2-Propenoic acid, C16-18-alkyl esters
- Cas Number:
- 90530-21-5
- IUPAC Name:
- 2-Propenoic acid, C16-18-alkyl esters
- Details on test material:
- - Name of test material (as cited in study report): Stearylacrylat, Synative MM SA, Stearyl 1618
- Physical state: solid
- Analytical purity: The purity of the test item is 95.1 corr. area % as a sum of two main compounds C16 and C18-fatty alcohol acrylate.
- Lot/batch No.: 0007943646
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Positive control reference chemical:
- methyl methacrylate
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
Any other information on results incl. tables
Incubation in rat liver S9 mix
The hydrolysis rate of 2 -Propenoic acid, C16 -alkyl ester is nearly parallel with that of 2 -Propenoic acid, C18 -alkyl ester. A slow but continously increase of acrylic acid was seen after 60 min, maximum degradation of 20% until the end of exposere time.
Incubation in rat plasma
A decrease of 2 -Propenoic acid, C16 -18 -alkyl ester of 50 % was seen in the first 10 min, until the end of the exposure time (120 min) the decrease of the alkyl esters was 75%. A continuous increase in acrylic acid of 25% is visible over the duration of the experiment.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
