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EC number: 402-920-1 | CAS number: 103300-89-6 N-6-TRIFLUORACETYL-L-LYSYL-L-PROLIN; T.F.A. LYS PRO; TFA-LYS-PRO
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-04-22 to 1993-05-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- as specified in Directive 84/449/EEC (Sixt Amendment to Directive 67/548/EEC, Annex V)
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.89
- pH:
- 6.3
- Remarks on result:
- other: Temperature was given as range : 22.8 to 23.5 °C
- Conclusions:
- The n-octanol/water partition coefficient of ε-Trifluoroacetyl-L-lysyl-L-proline (at 22.8 to 23.5°C) was determined in a test according to EU Method A.8 (1984) and was given as the mean of all six determined values: Pow = 0.013; log Pow = -1.89
Reference
Measured Results |
|||||
Test No. (O/W) |
concentration in n-octanol [mg/L] |
concentration in water [mg/L] |
Pow |
mean value Pow |
pH value of the aqueous phase |
A (1/1) |
15.7 |
1269.61 |
0.0124 |
0.013 |
6.3 |
B(1/1) |
16.22 |
1243.90 |
0.0130 |
6.2 |
|
C (2/1) |
31.87 |
2499.97 |
0.0128 |
0.013 |
6.2 |
D (2/1) |
31.79 |
2504.07 |
0.0127 |
6.2 |
|
E (1/2) |
8.14 |
655.66 |
0.0124 |
0.013 |
6.2 |
F(1/2) |
8.50 |
641.37 |
0.0133 |
6.4 |
|
Blank |
0.49 |
9.78 |
|
|
7.0 |
Balance of the substance amount |
||||
Test No. (O/W) |
basic content from stock [mg] |
content found in n-octanol phase [mg] |
content found in water phase [mg] |
sum of found contents [%] |
A (1/1) |
25.81 |
0.31 |
25.39 |
99.6 |
B(1/1) |
25.81 |
0.32 |
24.88 |
97.6 |
C (2/1) |
51.62 |
0.64 |
50.00 |
98.1 |
D (2/1) |
51.62 |
0.64 |
50.08 |
98.2 |
E (1/2) |
12.91 |
0.16 |
13.11 |
102.9 |
F(1/2) |
12.91 |
0.17 |
12.83 |
100.7 |
Blank |
|
|
|
|
Description of key information
Pow = 0.013 => logPow = -1.89
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.89
- at the temperature of:
- 23 °C
Additional information
In a GLP study conducted according to Directive 92/69/EEC, A.8 (flask method) the partition coefficient of the test item was determined to be -1.89 at 22.8 - 23.5 °C.
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