Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 432-810-9 | CAS number: 1379976-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Adequacy of study:
- other information
Data source
Materials and methods
- Objective of study:
- other: Assessment of toxicokinetic behaviour
Results and discussion
Any other information on results incl. tables
Toxicity studies have shown no evidence for absorption
following oral administration.
Although there was no evidence of any dermal penetration in
the rat and rabbit, following occluded application, the
positive dermal sensitisation result in the guinea pig
demonstrated that some test substance was absorbed through
the skin in this species.
The results of the air elutriation study showed that the
test substance was of low respirability, with only 0.22% of
an inhaled dose capable of penetrating lower than the
nasopharyngeal region.
An assessment of potential absorption is also based upon its
physico-chemical properties, which suggest that the intact
molecule would be subject to some absorption across the
gastrointestinal mucosa following oral administration.
The poor aqueous solubility would promote biotransformation
of any absorbed molecule, because the intact molecule would
be unlikely to be excreted directly in urine. One of the
three equivalent methyl groups on the tertiary butyl moiety
is subject to progressive oxidation to the alcohol and
carboxylic acid, both of which may be excreted either
conjugated or non-conjugated. However, the whole butyl
group is more likely to be cleaved to leave a carboxylic
acid which would increase the polarity of the molecule,
thereby promoting urinary excretion. Other methyl groups
may also be oxidised and conjugated similarly. Hydroxylation
of the fluorophenyl ring would also increase the polarity of
the molecule. Any metabolites eliminated via bile would be
excreted in faeces with the unabsorbed dose.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.