Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-306-6 | CAS number: 57-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Endpoint summary
Administrative data
Description of key information
Additional information
The ready biodegradability of „creatine monohydrate“ was determined according to OECD Guideline 301 E at a nominal concentration of 20 mg DOC/L. Creatine monohydrate degraded by 71.2 % after 10 days of incubation at 21 ± 0.4 °C fulfilling the “10-d window” criterion. Therefore, creatine monohydrate can be classified as"readily biodegradable". This result is used for the classification of creatine (CAS 57 -00 -1) in a read-across approach.
Further biodegradation studies do not have to be conducted:
In accordance with Column 2 adaptation statement of REACH Annex IX, simulation testing on ultimate degradation in surface water (information requirement 9.2.1.2), soil simulation testing (information requirement 9.2.1.3), as well as sediment simulation testing (information requirement 9.2.1.4), do not need to be conducted as the substance is readily biodegradable (CSR section 4.1.2.1.2 Biodegradation in water: screening test). Besides, the test substance entering the water is not likely to sorb onto suspended solids and sediment, and does not have a high potential for adsorption to soil, based upon the measured log Kow. Justification for read-across: For the aquatic REACH endpoint 9.2.1.1 ”Ready biodegradability” the results obtained with creatine monohydrate can be used for the registration of creatine: When dissolved in water there is no chemical difference between “creatine monohydrate” and “creatine”. The crystal water contained in creatine monohydrate does not for the toxicity profile of the substance. Besides, the measurements and results of this ready biodegradability study are not based on mg substance/L, but on mg DOC/L, which is the same for “creatine monohydrate” and “creatine” (both substances have the same carbon content). Therefore, the results obtained for “creatine monohydrate” can directly be used in the REACH substance registration for “creatine”. Therefore, “creatine” can be classified as readily biodegradable.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)