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EC number: 234-585-0 | CAS number: 12013-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In vitro studies were performed on
- skin corrosion and irritation, with the Reconstructed Human Epidermis (RHE) Model
- eye irritation with the Bovine Cornea Opacity and permeability Assay (BCOP)
All the test are recent (2010) and were performed according to standard OECD Test Guidelines and GLP standards.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
As indicated in OECD 404 and 405 test guidelines,
screening for existing data indicating irritation or corrosion potential
should precede testing. Screening for skin and eye corrosion/irritation
potential by Toxtree (Cramer rule) analysis was performed (see
attachment), but only resulted in unknown or no classification.
Literature and data on pH and buffering capacity testing are attached,
demonstrating that pH in 10% suspension was 12,1-12,3 and buffering
capacity was 4,48 g NaOH/100 g Calcium stannate. The conclusions are
that, despite the extreme pH, the buffering capacity is too low to
expect corrosive properties. Hence, in vitro testing was needed.
A key in vitro skin corrosion study with a
three-dimensional reconstructed human epidermis (RHE) model was
conducted with Calcium stannate according to GLP and the OECD 431 test
guideline(Hey S., Evonik Industries, 2010).The study was considered
reliable, adequate and relevant and considered as key study for skin
corrosion testing.
Two RHE cultures were topically exposed to 30.8 mg (±2.3 mg) Calcium
stannate. Corrosive effects were determined after 3 min and 1 h exposure
by determining cell viability using the standard MTT Assay.Application
of Calcium stannate resulted in a mean cell viability of 91.0 % (±9.2 %)
after 3 min exposure period and 93.9 % (±14.5 %) after 1 h exposure
period. It is concluded that Calcium stannate has to be predicted as non
corrosive to skin.
A key in vitro skin irritation study with a
three-dimensional reconstructed human epidermis (RHE) model was
conducted with Calcium stannate according to GLP and the OECD 439 test
guideline (Heisler E. , Evonik Industries,2010). Three RHE cultures were
topically exposed to 61.6 mg (±4.6 mg) Calcium stannate for a 60 min (±1
min) period time. The cell viability was determined after an additional
42 h (±1 h) post incubation period. For the analysis of the tissue
viability, the standard MTT Assay was used. The viability of the
negative control was set to 100%. The acceptance criteria for the study
with negative and positive controls were met and the study was
considered reliable, adequate and relevant. Application of Calcium
stannate resulted in a mean cell viability of approximately 66 % after
60 min (±1 min) exposure. It is concluded that Calcium stannate has to
be predicted as not irritating to skin according to the OECD Test
Guideline 439.
A key in vitro study for eye irritation was
conducted with Calcium stannate according to GLP and the OECD 437 test
guideline (Bovine Cornea Opacity and permeability Assay (BCOP)
(Heppenheimer A., 2010). The background opacity of fresh bovine corneas
(t0) was determined, followed by application of a 20% (w/v) Calcium
stannate to corneas incubated for 240 minutes at 32±1°C. After the
incubation phase, Calcium stannate was rinsed from the corneas and
opacity was measured again (t240). Thereafter, the permeability of the
corneas was determined while application of 1 mL of sodium fluorescein
for 90 minutes at 32±1°C. The acceptance criteria for the study with
negative and positive controls were met and the study was considered
reliable, adequate and relevant. Calcium stannate did not cause opacity
of the corneas compared with the results of the negative control, but
increased the permeability of the corneas. The calculation mean in vitro
score was 18.75. According to the criteria mentioned in the report,
Calcium stannate was considered as a mild irritant. According to OECD
437, Calcium stannate is considered as not corrosive or severe eye
irritating. On the SDS it should be mentioned that Calcium stannate is
mildly irritating to eyes based on the precautionary principle.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Calcium tin trioxide does not fulfill the classification criteria for skin corrosion or irritation, based on negative results in studies with a three-dimensional reconstructed human epidermis (RHE) model.
Calcium tin trioxide does not fulfill the classification criteria for eye corrosion or severe eye irritation, based on negative results in the BCOP test.
Calcium tin trioxide is inconclusive on non classification for eye irritation because negative results in the BCOP test are not conclusive for a non classification; for a final conclusion in vivo testing is needed but this is not required in REACH for this kind of dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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