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EC number: 279-815-0 | CAS number: 81782-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 12th June 1989 to 13th July 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A GLP study performed in accordance with generally accepted scientific principles, with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Type of study / information:
- This endpoint provideds information determined from an in vivo photoallergenicity study. The test material was applied using a similar procedure to the standard maximisation test, however, the test sites were also subjected to an irratiation regimen during the course of the test to determine the photoallerginicity.
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CTFA Safety Testing Guidelines, The Cosmetic, Toiletry and Fragrance Association, Inc. Washington, D.C. 20005; "Guidelines for Evaluating Photodermatitis" pp. 9-11
- Deviations:
- no
- Principles of method if other than guideline:
- Ten albino female guinea pigs were used as a control group and twenty females were used in the treatment group (using the highest non-irritating concentration of 30 %). The reactions to the skin of the irradiated and not radiated test sites were compared.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methyl-3-decen-5-ol
- EC Number:
- 279-815-0
- EC Name:
- 4-methyl-3-decen-5-ol
- Cas Number:
- 81782-77-6
- Molecular formula:
- C11H22O
- IUPAC Name:
- 4-methyldec-3-en-5-ol
- Test material form:
- liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
Erythema and Edema Scoring
- All animals were scored 0 for both the irradiated and non-radiated test sites at each of the concentrations tested.
Local Symptoms
- Control and the test group displayed the same symptoms:
Erythema and edema were observed on all application areas from Day 2 to 7.
Necrosis was observed from Day 8 to 16 and exfoliation from Day 17 until termination on Day 25.
- Epidermal Application:
No symptoms were observed in either the test or control groups.
Mortality/Viability
One female died spontaneously on Day 23.
Macroscopical Findings
- The lungs were not collapsed but reddened in the female found dead on day 23.
Clinical Signs
- No systemic symptoms were observed.
Body Weights
- Two females lost weight during the acclimatization period.
- One female lost weight during treatment.
Table 2. Body Weights (g)
Acclimatisation |
Group 1 |
Group 2 |
|
Day 1, Week 1 |
Mean |
431.6 |
432.7 |
SD |
17.5 |
16.9 |
|
N |
10 |
20 |
|
Treatment |
|
||
Day 1, Week 1 |
Mean |
466.3 |
474. |
SD |
27.3 |
29.7 |
|
N |
10 |
20 |
|
Day 25, Week 4 |
Mean |
530.4 |
544.7 |
SD |
48.0 |
36.2 |
|
N |
10 |
19 |
Applicant's summary and conclusion
- Conclusions:
- The test material was determined to be not sensitising in the photoallergenic guinea pig maximisation test.
- Executive summary:
The photoallergenicity caused by exposure to the test material combined with irradiation was determined in a GLP compliant study conducted in accordance with generally accepted scientific principles. The test material was applied as a 10% dilution in acetone/ethanol (1:1) for the induction, while the test material was applied at concentrations of 30, 10, 3 and 1 % for the challenge. During the challenge animals were exposed to the test material on both the left and right flanks, where only the left was irradiated with UV-A light.
Under the conditions of the study no skin responses were observed after the induction or on the irradiated and non-irradiated challenge sites. Based on the results, it can be concluded that the test material possesses no photoallergic potential for guinea pigs and thus the likelihood that the test material would cause a reaction in humans is low.
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