Registration Dossier
Registration Dossier
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EC number: 234-521-1 | CAS number: 12007-89-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- other: Case study
- Rationale for reliability incl. deficiencies:
- other: Not applicable as this is a case study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Accidental boric acid poisoning following the ingestion of household pesticide.
- Author:
- Hamilton RA & Wolf BC
- Year:
- 2 007
- Bibliographic source:
- J. Forensic Sci. 52 (3) 706 – 8
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The reference describes a poisoning incident in humans.
- GLP compliance:
- no
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- Boric acid
- Details on test material:
- - Name of test material: Boric acid-containing roach powder.
Constituent 1
Method
- Subjects:
- Number of subjects exposed: One
- Sex: Female
- Age: 18-months old
- Known diseases: The child had no documented past medical history. - Route of exposure:
- oral
- Reason of exposure:
- accidental
- Exposure assessment:
- measured
Results and discussion
- Clinical signs:
- The child was pronounced dead at the emergency room. No clinical signs were therefore described.
- Results of examinations:
- A post-mortem examination was performed 28 h after the child’s death. The stomach contained 80 cc of thick green-brown liquid and the small and large intestines focally contained a light brown, liquid material. Routine toxicological studies were negative. A heart-blood borate concentration of 8316 mcg/dL (reference range toxic > 2000 mcg/dL) and a gastric content borate concentration of 6048 mg/L.
Applicant's summary and conclusion
- Conclusions:
- The case of an 18-month-old child who died following the accidental ingestion of boric acid-containing commercially available roach pesticide product was described. A post-mortem examination was performed 28 h after the child’s death. The stomach contained 80 cc of thick green-brown liquid and the small and large intestines focally contained a light brown, liquid material. Routine toxicological studies were negative. A heart blood borate concentration of 8316 mcg/dL (reference range toxic > 2000 mcg/dL) and a gastric content borate concentration of 6048 mg/L. The cause of death was attributed to accidental acute borax toxicity.
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