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Diss Factsheets
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EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Read-across of data for an analogous chemical. The target chemical and the source chemical are very closely related alkyl acrylate compounds. They differ only by the addition of a methyl group in the butyl portion of the molecule. Both molecules are expected to be metabolized via the same hydrolysis and enzymatic pathways. The data from the source chemical are experimental results from well documented studies which meet basic scientific principles and are considered to be acceptable with restrictions. Comparable to guideline with acceptable restrictions (dose level not up to cytotoxic range; neither Escherichia coli strain WP2 uvrA pKM101a nor S. typhimurium strain TA102 were employed in this study for the detection of oxidising mutagens and cross-linking agents)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- The study was conducted according to the method described by Ames (1975) with minor modifications.
Ames BN et al. (1975). Mut. Res. 31: 347-364 - GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- IUPAC Name:
- butyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Butyl acrylate
- Physical state: liquid
- Analytical purity: approximately 99.6 %
- Impurities (identity and concentrations): 0.4% butylpropionate, 15 ppm methyletherhydroquinone
Constituent 1
Method
- Target gene:
- Histidin auxotrophy
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 induced Sprague-Dawley-rat liver S-9 mix
- Test concentrations with justification for top dose:
- 3.15 to 1000 nL per plate (2.84, 9.0, 28.4, 90.0, 283.5 and 900.0 µg per plate) Calculation (µg/plate) based on density of the test substance (0.9 g/mL).
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: with S9: 2-Aminoanthracene, Benzo(a)pyrene, 3-Methylcholanthrene and trans-N-Methyl-4-Aminostilbene; without S9: N-Methyl-N-Nitro-N-Nitrosoguanidine, Benzo(a)pyren-4-5-oxide
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Test substances |
Dose / plate (µg) |
TA1535 |
TA1537 |
TA98 |
TA98 TCPO* |
TA100 |
Butyl acrylate |
2.84 |
35 |
23 |
68 |
50 |
138 |
9.0 |
27 |
26 |
64 |
56 |
107 |
|
28.4 |
27 |
30 |
60 |
61 |
124 |
|
90.0 |
28 |
32 |
61 |
65 |
123 |
|
283.5 |
22 |
25 |
52 |
54 |
130 |
|
900.0 |
26 |
23 |
56 |
54 |
112 |
|
Positive Control-1 |
3.15 |
- |
- |
245 |
308 |
387 |
6.3 |
231 |
96 |
1298 |
- |
1550 |
|
10 |
519 |
58 |
- |
- |
1465 |
|
20 |
890 |
- |
- |
- |
- |
|
Positive Control-2 |
10 |
21 |
150 |
599 |
781 |
520 |
Positive Control-3 |
90 |
22 |
85 |
800 |
676 |
3495 |
Positive Control-4 |
10 |
- |
- |
- |
- |
448 |
Vehicle Control |
21 |
24 |
49 |
62 |
110 |
- Not done
Positive Control-1: 2-Aminoanthracene
Positive Control-2: Benzo(a)pyrene
Positive Control-3: 3-Methylcholanthrene
Positive Control-4: trans-N-Methyl-4-Aminostilbene
* 60 nl of epoxide hydratase inhibitor (1,1,1 Trichloro- propene-2,3-oxide) was added to each plate dissolved in 10 µl DMSO
Mean number of revertants without metabolic activationTest substances |
Dose / plate (µg) |
TA1535 |
TA1537 |
TA98 |
TA100 |
Butyl acrylate |
2.84 |
19 |
10 |
11 |
97 |
9.0 |
13 |
14 |
16 |
149 |
|
28.4 |
16 |
12 |
18 |
140 |
|
90.0 |
20 |
8 |
11 |
130 |
|
283.5 |
25 |
9 |
16 |
126 |
|
900.0 |
21 |
11 |
15 |
135 |
|
Positive Control-1 |
1 |
903 |
7 |
19 |
232 |
3.15 |
8500 |
31 |
29 |
4250 |
|
10 |
31000 |
39 |
51 |
9250 |
|
Positive Control-2 |
2 |
17 |
572 |
3650 |
1060 |
Vehicle Control |
19 |
8 |
15 |
117 |
- Not done
Positive Control-1: N-Methyl-N-Nitro-N-Nitrosoguanidine
Positive Control-2: Benzo(a)pyren-4-5-oxide
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative - Executive summary:
The results presented in this summary are experimental results for the source chemical n-butyl acrylate. The results are considered to be appropriate for read-across to the target chemical 2-methylbutyl acrylate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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