Registration Dossier
Registration Dossier
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EC number: 204-070-5 | CAS number: 115-19-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report - 2-Methylbut-3-yn-ol
- Author:
- BASF AG
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- internal BASF method was used, which was in large part equivalent to OECD Guideline 402
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methylbut-3-yn-2-ol
- EC Number:
- 204-070-5
- EC Name:
- 2-methylbut-3-yn-2-ol
- Cas Number:
- 115-19-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 2-methylbut-3-yn-2-ol
- Details on test material:
- - Analytical purity: 98.5%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.83, 2.84, 2.77 kg
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 ml/kg bw
- Concentration (if solution): 100% - Duration of exposure:
- 24 h
- Doses:
- 100%
- No. of animals per sex per dose:
- 3 male
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 9 days
- Frequency of observations and weighing: prior to begin and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 0.2 mL/kg bw
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- ca. 172 mg/kg bw
- Mortality:
- no deaths occured
- Clinical signs:
- other: no effects observed
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
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