2-dodecylhexadecan-1-ol

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Justification for type of information:

Please see read-across justification document in Chapter 13

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 10 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

Experimental data on 2-hexyldecan-1-ol and 2-octyldodecan-1-ol are available showing no acute toxicity to fish up to the limit of water solubility. In addition data on a guerbet alcohol with C32 -36 show also no toxicity to fish within the range of water solubility. It is therefore expected that 2-Dodecylhexadecan-1-ol shows no acute toxicity to fish up to the limit of water solubility.

Description of key information

Experimental data on three representatives of the category (C16, C20 and C32/36) show no acute toxicity to fish up to the limit of water solubility. These results were cross-read to 2-decyltetradecanol.

Additional information

2-Dodecylhexadecan-1-ol is a member of the Guerbet Alcohols, which comprises a range of branched long chain alcohols C12-32. It is also structurally related to the substances of the OECD SIDS Long Chain Alcohols (LCA) categories, comprising a range of straight and branched long chain alcohols C6-22. As defined in the ‘Read Across Justification Document’ section 13, data provided for these categories is representative of 2-dodecylhexadecan-1-ol and suitable for assessment purposes. Experimental data for the Guerbet and LCA categories has been evaluated and trends in the environmental fate of long chain alcohols was used to extrapolate to the C28 alcohol, 2-dodecylhexadecan-1-ol for ecotoxicological endpoints.

No data on short-term toxicity of 2-dodecylhexadecan-1-ol to fish are available. However, reliable studies are available for four representatives of the Guerbet alcohols category; 2-butyloctan-1-ol, 2-hexyldecan-1-ol, 2-octyldodecan-1-ol, and alcohols C32-36 branched.

Only with the short chain Guerbet alcohol 2-butyloctanol acute toxicity was observed in the fish. The C12 Guerbet alcohol showed acute toxicity to Oncorhynchus mykiss with an effects concentration of 0.48 mg/L. In contrast, no acute toxicity to fish at the level of water solubility was observed for 2-hexyldecanol, 2-octyldodecanol and branched C32-36 alcohols as with their equivalent linear analogues (C16, C20 and C32-36 long chain alcohols). Acute effects data for two fish species ranged from 3,000 mg/L to >10,000 mg/L. This is in agreement with the findings of the OECD SIDS report (described above) that the longest chain alcohols are unlikely to exhibit acute toxicity to aquatic organisms at the low solubility limits.

Adequate reliable tests with substances in the same category as 2-Dodecylhexadecan-1-ol show no acute toxicity to fish up to limit of solubility.