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Diss Factsheets
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EC number: 431-250-2 | CAS number: 171850-30-9 ODCQA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three male rats received a single oral administration of 2000 mg/kg test material, by gavage. The test material was dosed as a 20% suspension in 0.5% methylcellulose. Test animals were observed for 14 days following test material administration.
- GLP compliance:
- not specified
- Test type:
- other: similar to acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- EC Number:
- 431-250-2
- EC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Cas Number:
- 171850-30-9
- Molecular formula:
- C10H5NO3Cl2
- IUPAC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Details on test material:
- DCHQ-acid
Appearance: white solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No further information is available on test animals and environmental conditions.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% methylcellulose
- Details on oral exposure:
- The test material was dosed as a 2-0% suspension in 0.5% methylcellulose.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: test animals were weighed on study days 1, 2, 8 and 15
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the test period.
- Clinical signs:
- other: There were no clinical signs indicative of systemic toxicity.
Any other information on results incl. tables
Individual Bodyweights
The table shows the bodyweight in grams of the individual rats following a single oral gavage dose of the test material at 2000 mg/kg
Animal Number |
Test day 1 |
Test day 2 |
Test day 8 |
Test day 15 |
94A3783 |
176.8 |
186.1 |
214.4 |
235.4 |
94A3784 |
176.2 |
186.4 |
211.9 |
227.9 |
94A3785 |
174.8 |
195.5 |
212.8 |
232.1 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the acute oral LD50 of the test material was estimated to be greater than 2000 mg/kg in male Fischer rats.
- Executive summary:
Under the conditions of the study, the acute oral LD50 of the test material was estimated to be greater than 2000 mg/kg in male Fischer rats. This study does not allow definitive classifcation and labelling of the substance since the sample tested was a 20% suspension in 0.5% methylcelluose. Nevertheless, in the absence of signs indictative of toxicity there is no need to classify the substance.
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