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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report date:
1994

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Three male rats received a single oral administration of 2000 mg/kg test material, by gavage. The test material was dosed as a 20% suspension in 0.5% methylcellulose. Test animals were observed for 14 days following test material administration.
GLP compliance:
not specified
Test type:
other: similar to acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
EC Number:
431-250-2
EC Name:
5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
Cas Number:
171850-30-9
Molecular formula:
C10H5NO3Cl2
IUPAC Name:
5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
Details on test material:
DCHQ-acid
Appearance: white solid

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male
Details on test animals or test system and environmental conditions:
No further information is available on test animals and environmental conditions.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.5% methylcellulose
Details on oral exposure:
The test material was dosed as a 2-0% suspension in 0.5% methylcellulose.
Doses:
2000 mg/kg
No. of animals per sex per dose:
3 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: test animals were weighed on study days 1, 2, 8 and 15

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
All animals survived the test period.
Clinical signs:
other: There were no clinical signs indicative of systemic toxicity.

Any other information on results incl. tables

Individual Bodyweights

 

The table shows the bodyweight in grams of the individual rats following a single oral gavage dose of the test material at 2000 mg/kg

Animal Number

Test day 1

Test day 2

Test day 8

Test day 15

94A3783

176.8

186.1

214.4

235.4

94A3784

176.2

186.4

211.9

227.9

94A3785

174.8

195.5

212.8

232.1

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of the study, the acute oral LD50 of the test material was estimated to be greater than 2000 mg/kg in male Fischer rats.
Executive summary:

Under the conditions of the study, the acute oral LD50 of the test material was estimated to be greater than 2000 mg/kg in male Fischer rats. This study does not allow definitive classifcation and labelling of the substance since the sample tested was a 20% suspension in 0.5% methylcelluose. Nevertheless, in the absence of signs indictative of toxicity there is no need to classify the substance.