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EC number: 203-757-7 | CAS number: 110-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (2.6 mg/L in aqua dest) for Daphnia magna (OECD 202)
Key value for chemical safety assessment
Additional information
One study investigating the acute toxicity to aquatic invertebrates of Dihexyl adipate (CAS 110-33-8) is available. The study was conducted under GLP conditions according to OECD guideline 202 using Daphnia magna as test organism (Harris, 2013). The test organisms were exposed to an aqueous solution of the test item at concentrations of 1.0, 3.2, 10, 32 and 100% v/v saturated solution for 48 hours at a temperature of 20 °C to 21 °C under semi static test conditions. The test item solution was prepared by stirring an excess (50 mg/L) of test item in test medium using a propeller stirrer at approximately 1500 rpm for 24 hours. After the stirring period any undissolved test item was removed by filtration (0.2 µm Gelman Acrocap filter, first approximate 500 mL discarded in order to pre-condition the filter) to produce a 100% v/v saturated solution of the test item from which dilutions were prepared to give the remainder of the test series. The number of immobilized Daphnia was recorded after 24 and 48 hours. Analysis of the freshly prepared test media at 0 and 24 hours showed measured test concentrations of 0.538 and 0.415 mg/L respectively. A decline in measured test concentration was observed in the old or expired test media at 24 and 48 hours to less than the limit of quantitation (LOQ) of the analytical method employed, which was determined to be 0.0022 mg/L, and 0.0111 mg/L respectively. This decline in concentration was considered to be due to the unstable nature of the test item. Given this decline in measured test concentrations over each 24 hour period it was considered justifiable to base the results on the time weighted mean measured test concentrations of the test media to give a "worst case" analysis of the data. The time weighted mean measured test concentration was calculated to be 0.099 mg/L. The 48-Hour EC50 based on the time weighted mean measured test concentrations test media was greater than 0.099 mg/L and correspondingly the No Observed Effect Concentration was 0.099 mg/L.
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