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EC number: 201-947-4 | CAS number: 89-87-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-05-05 to 1989-03 (revised 1991-11)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study according to OECD TG.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Deviations:
- no
- Remarks:
- however, deviations from the protocol occurred.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 4-nitro-m-xylene
- EC Number:
- 201-947-4
- EC Name:
- 4-nitro-m-xylene
- Cas Number:
- 89-87-2
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 2,4-dimethyl-1-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- Continous dietary administration to rats for 28 days.
- Frequency of treatment:
- Continous treatment, feed was available ad libitum.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 ppm, 100 ppm, 600 ppm, 3000 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5 male and 5 female rats per dose
- Control animals:
- yes, plain diet
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 600 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: - At this dose (mid-dose) none of the parameters determined in the course of this study showed changes that were considered to be of toxicological significande - 600 ppm corresponds to an actual substance intake of about 60 mg/kg body weight per day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Changes observed were the following:
- slight growth retardation in the mid- and top-dose group, while the retardation in the mid-dose group was considered of no toxicological relevance, since it was only slight and not statistically significant
- increases in liver weight, accompanied by decreases in total protein and albumin content in plasma (top-dose)
- in males of the top-dose: decreases in red blood cell count and haemoglobin concentration, increased adrenals weight (top-dose)
- in females: increased spleen weight
Applicant's summary and conclusion
- Conclusions:
- It is concluded that the no-toxic effect level of 4-nitro-1,3-dimethylbenzol in the present study is 600 ppm in the diet. This level is equivalent to a nominal overall intake of about 60 mg/kg body weight per day.
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