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Registration Dossier
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EC number: 205-569-0 | CAS number: 142-88-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Prediction report
- Title:
- 26.12.2012 17:04 [R]: 880 mg/L "Human Health Hazards#Acute Toxicity" for 142-88-1
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox Version 3.0
Materials and methods
Test guideline
- Guideline:
- other: Not Applicable
- Principles of method if other than guideline:
- QSAR prediction is done using the OECD QSAR Toolbox Version 3.0
- GLP compliance:
- not specified
- Test type:
- other: Acute Rodent Inhalation Toxicity Test
Test material
- Reference substance name:
- Piperazine adipate
- EC Number:
- 205-569-0
- EC Name:
- Piperazine adipate
- Cas Number:
- 142-88-1
- Molecular formula:
- C6H10O4.C4H10N2
- IUPAC Name:
- piperazine adipate
- Details on test material:
- SMILES:C(=O)(O)CCCCC(=O)O_C1CNCCN1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: Inhalation: Vapor
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 880.496 ppm
- Based on:
- test mat.
- Exp. duration:
- 8 h
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)CCCCC(=O)O_C1CNCCN1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.856
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.62
Applicant's summary and conclusion
- Interpretation of results:
- other: Other: Slightly toxic or Practically nontoxic
- Conclusions:
- The lethal concentration (LC50) of rat via inhalation: vapor route for piperazine adipate is estimated to be 880.49 mg/l. Based on this value it can be concluded that piperazine adipate is practically non toxic substance via inhalation route.
- Executive summary:
The lethal concentration (LC50) of rat via inhalation: vapor route for piperazine adipate is estimated to be 880.49 mg/l. Based on this value it can be concluded that piperazine adipate is practically non toxic substance via inhalation route.
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