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EC number: 416-740-6 | CAS number: -
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Short term and long term toxicity in earthworm - read-across data (1 key short-term study and 1 key long-term study)
Read-across findings indicate that the submission substance is not expected to cause short-term or long-term toxicity to earthworms.
Key value for chemical safety assessment
Additional information
No earthworm toxicity data are available for the terephthalate submission substance, CAS No. 162030-42-4. Also there are no read-across data available for terephthalate surrogates like DEHT. In light of this, the next likely and logical read-across surrogate material to consider would be the isomeric alkyl phthalate analogues. Relevant earthworm toxicity data have been reported for dinonyl phthalate (DINP) (CAS No. 68515-48-0) and di-isodecyl phthalate (DIDP) (CAS No. 68515-49-1), which can provide some useful read-across assessment for terephthalate isomeric materials like the submission substance, CAS No. 162030-42-4. From a structure activity relationship perspective, the long-chain alkyl phthalates and the corresponding long-chain terephthalates are chemically similar and related in that they are isomeric analogs of each other. From a toxicological perspective, one would expect terephthalates (i.e., 1,4-benzenedicarboxylic acid, diesters) to have similar toxicity to the corresponding phthalate materials (i.e., 1,2-benzenedicarboxylic acid, diesters) owing to their similar physical chemical characteristics (e.g., water insolubililty, log Kow, and bioavailability). Hence, the available read-across data for the corresponding C9-10 phthalate esters such as DINP or DIDP, can help assess the potential terrestrial toxicity of the submission terephthalate material (CAS No. 162030-42-4), especially in earthworms.
Read-across results from a 14-day OECD 207 earthworm study showed that di-isodecyl phthalate (DIDP) did not cause any toxicity at the highest soil concentrations tested in natural and artificial soils (i.e., 7664 or 8435 mg/kg natural or artificial soil dw, measured, respectively) (Exxon Biomed Sci., 1996a). The 14-day LC50 value was greater than 7664 mg/kg natural soil or greater 8435 mg/kg soil artificial soil (dw) and the 14-day NOEC value was greater than 7664 or 8435 mg/kg soil dw with no mortality observed. Overall, these findings indicate that DIDP was not acutely toxic and caused no mortality or adverse effects in earthworms exposed to soil concentrations as high as 7664 to 8435 mg/kg dw.
In addition, results from a 56-day earthworm reproduction study show that DINP did not cause reproductive toxicity at the highest concentrations tested in artificial soil. The 56-day NOEC was 982 mg/kg (d.w.) in artificial soil (ExxonMobil Biomed. Sci., 2009).
As discussed above, in the absence of any terephthalate surrogate read-across data, it is reasonable from a structure activity relationship (SAR) and chemical category perspective to use the long-chain C8-C13 phthalate esters as alternative surrogates to estimate the potential toxicity of the terephthalate diesters of similar chain length.
Conclusion: Based on the read-across acute and chronic earthworm toxicity data for DIDP and DINP, the submission substance (EC No. 416-740-6) would not be expected to cause short-term or long-term toxicity to earthworms.
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