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EC number: 939-455-3 | CAS number: 1469983-49-0
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 16 May 2012 to 25 January 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2012-12-15
- Type of method:
- effusion method: vapour pressure balance
- Remarks:
- Knudsen effusion cell
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Transition / decomposition:
- no
- Conclusions:
- The vapour pressure of the test item extrapolated at 20 °C was 0.000000023 Pa.
- Executive summary:
The vapour pressure of the test item (= substance EC 939-455-3) was investigated in a GLP-compliant study performed in accordance with OECD Guideline 104 (Vapour Pressure Curve) and EU Method A.4 (Vapour Pressure) using the effusion method. The vapour pressure of the test item was 2.3x10-8 Pa at 20°C (extrapolated value). The test item is considered as not volatile.
Reference
Results:
A first assay was made; the mass of sample weighed was 2.59 mg. The sample was placed in a Knudsen effusion cell with an aperture size of A = 279.9 μm. Then the cell was placed in the apparatus. Temperature steps at 40, 45 and 50 °C were made but no loss of mass was recorded. A second assay was made; the mass of sample weighed was 4.89 mg. The sample was placed in a Knudsen effusion cell with an aperture size of A = 279.9 μm. Then the cell was placed in the apparatus. Temperature steps at 70 and 85 °C were made but no loss of mass was recorded. A third assay was made; the mass of sample weighed was 4.41 mg. The sample was placed in a Knudsen effusion cell with an aperture size of A = 279.9 μm. Then the cell was placed in the apparatus.
The temperature was increased up to about 110 °C in order to detect a loss of mass. This temperature step was taken into account.
Another temperature step at 120 °C was made but no linear loss of mass was recorded.
The temperature was increased up to 130 and then 140 °C and these steps were taken into account. The test item (powder) was compacted after the experimentation. No degradation of the test item was observed.
The vapour pressure of the test item was calculated by the “Knudsen software”. The calculation results are summarized in the following table.
| Test temperature t (°C) | Test temperature T (K) | 1/T (K-1) | Experimental vapour pressure P (Pa) | Log P (Pa) | Knudsen effusion cell size (μm) |
| 110 | 383.15 | 2610*10-3 | 9.3932*10-3 | -2.027 | 279.9 |
| 130 | 403.15 | 2480*10-3 | 6.9995*10-2 | -1.155 | |
| 140 | 413.15 | 2420*10-3 | 2.0173*10-1 | -0.695 |
The molecular weight of Cocamidopropyl Hydroxysultaine (C12 acyl chain) is 422.6 g/mol.
The graph log P = f (1/T) was then plotted to extrapolate the vapour pressure at 20 °C (see Attachment 1).
Description of key information
The vapour pressure of the substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) was investigated in a GLP-compliant study (Ricau, 2013) performed in accordance with OECD Guideline 104 (Vapour Pressure Curve) and EU Method A.4 (Vapour Pressure) using the effusion method. The vapour pressure of the substance was 2.3x10-8 Pa at 20°C (extrapolated value). The substance is considered as not volatile.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
The vapour pressure of the substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) was investigated in a GLP-compliant study (Ricau, 2013) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.
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