2-methylvaleraldehyde

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study is well documented and acceptable for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-methylvaleraldehyde

EC Number:

204-605-2

EC Name:

2-methylvaleraldehyde

Cas Number:

123-15-9

Molecular formula:

C6H12O

IUPAC Name:

2-methylpentanal

Details on test material:

- Name of test material: Methylpentanal

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Firma WIGA, Sulzfeld, Germany (FRG)
- Age at study initiation: no data
- Weight at study initiation (mean): Males: 205 g (test group), 213 g (control group); Females: 195 g (test group), 192 g (control group)
- Fasting period before study: no data
- Housing: no data
- Diet: Herilan MRH of Firma H. EGGERSMANN KG, Germany (FRG), ad libitum
- Water: ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

IN-LIFE DATES: From: 1978-02-17 To: 1978-03-03

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Chamber, whole body inhalation
- Exposure chamber volume: 180 L
- Source and rate of air: 3000 L/h
- Method of conditioning air: Devolatizer at 90 °C
- System of generating particulates/aerosols: intermixture with flow of fresh air
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data

TEST ATMOSPHERE
- Brief description of analytical method used: Absorbed test substance was determined in Xylol by means of gaschromatography
- Samples taken from breathing zone: yes

VEHICLE
- Composition of vehicle: air

TEST ATMOSPHERE
- Particle size distribution: no data
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): no data

Analytical verification of test atmosphere concentrations:

yes

Remarks:

gaschromatography

Duration of exposure:

4 h

Concentrations:

9.7 mg/L (nominal)
8.4 mg/L (measured)

No. of animals per sex per dose:

10

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of weighing: at start, after 7 days and after 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: mortality and clinical signs, daily observed

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 8.4 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: Concentration: analytically verified

Mortality:

All animals survived (no mortalities occurred during the 14-days observation period).

Clinical signs:

other: Accelerated respiration, crusted noses, rough fur

Body weight:

No differences were observed compared to the control group.

Gross pathology:

No animal showed any abnormal finding at necropsy.