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EC number: 700-887-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
SKIN IRRITATION:
Potassium chloride:
For skin irritation propertis of potassium chloride an experiment was carried out according to OECD 439 and EU Test Method B.46 using commercially available reconstructed human epidermis (RHS) model EST-1000 (CellSystems, St.Katharinen, Germany).
Undissolved potassium chloride (KCl) was applied topically to the RHS model, i.e. 30 mg per insert (plus 30µl 0.9% NaCl to moisten and ensure good contact with the skin; three replicates). After an exposure a cell viability of 84.24% was measured. Thus, the results show that potassium chloride (KCl) does not have to be classified regarding skin irritation. This result is confirmed by a study conducted in rabbits by Marhold in 1972. Here also no signs of skin irritating potential were noted.
L-alanyl-L-glutamine:
For L-alanyl-L-glutamine an in vivo study in rabbits according to the OECD guideline 404 was conducted. At none of the foreseen observation time points after treatment erythema or edema could be ovserved. Therefore also L-alanyl-L-glutamine is considered to be not irritating to the skin.
Reaction mass of L-alanyl-L-glutamine and potassium chloride:
Based on the data available for both individual main components and in the absence of synergistic or antogonistic effects, the reaction mass of L-alanyl-L-glutamine and potassium chloride is considered to be not irritating to the skin.
EYE IRRITATION:
Potassium chloride:
There is an early publication available in which an experiment on rabbits is reported that examined the potential eye irritating property of potassium chloride.
500 mg potassium chloride was instilled into the eye for 24 hours which caused irritating effects of grade 3 / 10. No further detail is available from that study. In a respective study on skin irritation published in parallel by the same research group the result was recorded to be "0", indicative of no relevant skin irritation potential. To evaluate the significance of the result of the eye irritation study and the relevance of the observation for classification a plausibility check was performed by collecting some examples with the same "Marhold evaluation: eye grade 3/10 and skin : 0". These substances are NaNO2, Cas-Nr 7632-00-0; NH4Cl CAS-Nr 12125-02-9: AlF3 CAS-Nr 7784-18-1; CCl4 CAS-Nr 56-23-5: Isophthalic acid CAS-Nr. 121-91-5; Maleic acid CAS-Nr 110-16-7 and CAS-Nr 67-68-5. Only two of them are classified and labelled according to the respective guideline but all of them were reported in reliable reviews to cause irritation effects in the eyes of rabbits of different magnitude
Overall, based on the available data there is some evidence of an eye irritation potential of potassium chloride, but it is unclear whether the classification criteria are fulfilled..
In a recent in vitro study for evaluation of ocular irritant properties by using an artificial human 3D-Cornea model it is shown that potassium chloride (KCL) can be predicted as non-irritant under the condition of this test method.
Thus, overall, potassium chloride is considered as non-irritating to the eye.
L-alanyl-L-glutamine:
For L-alanyl-L-glutamine a GLP-compliant study according to the OECD guideline 404 was conducted in rabbits. Based on this L-alanyl-L-glutamine does not have eye irritating potential.
Reaction mass of L-alanyl-L-glutamine and potassium chloride:
Based on the data available for both individual main components and in the absence of synergistic or antogonistic effects, the reaction mass of L-alanyl-L-glutamine and potassium chloride is considered to be not irritating to the eye.
Justification for selection of skin irritation / corrosion endpoint:
Potassium chlroide:
For potassium chloride an vitro skin irritation study according to OECD guideline 439 was conducted. Based on this study the cell viability after treatment with potassium chloride was 84.24% and therefore clearly above the relevant 50% value. Due to this potassium chloride is considered to be not irritant to the skin. This is supported by an old in vivo study in rabbits conducted by Marhold in 1972. Here also no hinds for itrritating properties of potassium chloride were reported.
L-alanyl-L-glutamine:
For L-alanyl-L-glutamine an in vivo study in rabbits according to the OECD guideline 404 was conducted in rabbits. At none of the foreseen observation time points after treatment erythema or edema could be ovserved. Therefore also L-alanyl-L-glutamine is considered to be not irritating to the skin.
Overall assessment for reaction mass of L-alanyl-L-glutamine with potassium chloride:
Based on the data available for the 2 main components and in the absence of any evidence for synergistic or antagonistic properties, the reaction mass of L-alanyl-L-glutamine and potassium chlroide is considered to be not irritating to the skin.
Justification for selection of eye irritation endpoint:
Potassium chlroide:
For potassium chloride an vitro skin irritation study according to OECD guideline 439 was conducted. Based on this study the cell viability after treatment with potassium chloride was 84.24% and therefore clearly above the relevant 50% value. Due to this potassium chloride is considered to be not irritant to the skin. This is supported by an old in vivo study in rabbits conducted by Marhold in 1972. Here also no hinds for itrritating properties of potassium chloride were reported.
L-alanyl-L-glutamine:
For L-alanyl-L-glutamine an in vivo study in rabbits according to the OECD guideline 404 was conducted in rabbits. At none of the foreseen observation time points after treatment erythema or edema could be ovserved. Therefore also L-alanyl-L-glutamine is considered to be not irritating to the skin.
Overall assessment for reaction mass of L-alanyl-L-glutamine with potassium chloride:
Based on the data available for the 2 main components and in the absence of any evidence for synergistic or antagonistic properties, the reaction mass of L-alanyl-L-glutamine and potassium chlroide is considered to be not irritating to the skin.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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