Quaternary ammonium compounds, C12-18-alkyltrimethyl, chlorides

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Remarks:

Water solubulity as Critical Micelle Concentration (CMC)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2020

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Study was conducted as a part of determination of Critical Micelle Concentration. Well documented study and acceptable for assessment.

Qualifier:

according to guideline

Guideline:

other: Study was conducted as a part of determination of Critical Micelle Concentration (CMC) and water solubility was derived in the study.

Deviations:

not specified

Principles of method if other than guideline:

Study was conducted as a part of determination of Critical Micelle Concentration (CMC) and water solubility was derived in the study.

GLP compliance:

not specified

Type of method:

other: plate method

Key result

Water solubility:

ca. 1.05 g/L

Conc. based on:

not specified

Temp.:

25.09 °C

Remarks on result:

other: water solubility as CMC

Details on results:

CMC value: 1.05 g/L (23.7 mN/m)

Conclusions:

Under the study conditions, the water solubility as CMC for the test substance was determined to be 1050 mg/L.

Executive summary:

A study was conducted to determine the water solubility as CMC of test substance, C12 -18 TMAC (96.8% active) following plate method using an automated tensiometer. The CMC was determined to be 1050 mg/L at 25°C. Also, the surface tension at this concentration was been determined to be 23.7 mN/m. Under the study conditions, the water solubility as CMC for the test substance was determined to be 1050 mg/L (Oosterwijk, 2020).

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

15 June 2012

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Water solubility as critical micelle concentration (CMC)

Principles of method if other than guideline:

For surface active substances the critical micelle concentration (CMC) method is used as an alternative to the water solubility. The critical micelle concentration (CMC) is determined by measuring the surface tension of test substance solutions at different test substance concentration. For surface active substances which form micelles in solution, the surface tension decreases with increasing concentration until the CMC is reached. At concentrations above the CMC, the surface tension remains constant. The CMC is determined from a plot of the surface tension versus the logarithm of the test substance concentration.

GLP compliance:

not specified

Type of method:

other: critical micelle concentration (CMC)

Key result

Water solubility:

ca. 0.73 g/L

Conc. based on:

test mat.

Temp.:

21.31 °C

Remarks on result:

other: critical micelle concentration (CMC)

Conclusions:

Under the study conditions, the water solubility (critical micelle concentration) of the test substance was determined to be 0.73 g/L at 21.31°C.

Executive summary:

A study was conducted to determine the water solubility of the test substance, C12-14 TMAC (97% active) using the critical micelle concentration (CMC) method, which is recommended for surface active substances. Under the study conditions, the CMC of the test substance was determined to be 0.73 g/L at 21.31°C (Mangnus, 2019).

Description of key information

The water solubility of the test substance was determined using critical micelle concentration (CMC) method, which is recommended for surface active substances (Oosterwijk, 2020).

Key value for chemical safety assessment

Water solubility:

1.05 g/L

at the temperature of:

20 °C

Additional information

The CMC value of another test sample containing majorly C12 -14 chains was determined to 730 mg/L at 21.31 °C. The water solubility of the more representative test sample has been considered for the risk assessment.