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EC number: 203-026-2 | CAS number: 102-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: not irritating (eq. OECD 404, non-GLP, Key, Rel. 2).
Eye irritation: corrosive (eq. OECD 405, non-GLP, Key, rel.1)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: equivalent to OECD 404
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: polyethylene glycol 400
- Controls:
- not required
- Duration of treatment / exposure:
- 24
- Observation period:
- 30-60 min, 24, 48, 72 h, 7 and 14 d after removal of plaster
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible
- Other effects:
- no data
- Interpretation of results:
- GHS criteria not met
- Executive summary:
patch test: 4 h semiocclusive on 3 rabbits
result: mildly irritating
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 1, 24, 48 and 72 h after application
- Number of animals or in vitro replicates:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days (score of 3.0 on Day 7)
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days (score of 2.0 on Day 7)
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days (score of 3.0 at Day 7)
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days (score of 1.0 at Day 7)
- Other effects:
- 24 to 72 hours white, viscous discharge
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Classification: risk of serious damage to eyes
- Executive summary:
method: single application of 0.1 g 3,4 -dichlorophenyl isocyanate into the conjunctival sac of 3 rabbits
result: substance is irritating to the eye (risk of serious damage to eyes)
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
Referenceopen allclose all
time post application 1h 24h 48h 72h 7d
animal no 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3
chemosis 2 3 2 3 4 4 2 3 3 2 3 3 0 2 1
conjuctivae 2 2 2 3 3 3 3 3 3 2 3 3 0 2 1
iris 0 0 0 1 1 1 0 1 1 0 1 1 0 0 0
cornea 1 2 1 1 1 1 1 2 2 1 2 2 0 3 2
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
In a guideline study performed similarly to OECD TG 404 and under GLP (Kreiling/Jung, 1988), 3,4-dichlorphenyl isocyanate was found to be mildly irritating. Mean scores (24/48/42 hrs) for the three animals were 1.2 for erythema and 0.7 for oedema. Individual scores are not available.
Other studies reported similar results.
Based on the available data, 3,4-dichlorphenyl isocyanate is not classified as a skin irritant.
Eye irritation / damage
A guideline study performed according to OECD TG 405 and under GLP (Kreiling/Jung, 1988) revealed a risk of serious damage to eyes.
Mean (24/48/72 hrs) individual cornea opacity score : 1.0 / 1.7 / 1.7. No reversibility and increase effects were noted at Day 7.
Mean (24/48/72 hrs) individual iris score : 0.33 / 1.0 / 1.0. Recovery at Day 7.
Mean (24/48/72 hrs) individual conjunctival redness score : 2.3 / 3.0 /3.0. Partial recovery at Day 7.
Mean (24/48/72 hrs) individual conjunctival oedema (chemosis) score : 2.3 / 3.3 / 3.3. Partial recovery at Day 7.
This findings were supported by another study (Lamb, 1975) where 3,4 -dichlorphenyl induced strong ulceration of the conjunctiva after 5 min or 24 hours exposure.
Based on the available data, 3,4-dichlorphenyl isocyanate is classified as corrosive to the eyes.
Justification for classification or non-classification
Harmonised classification:
The substance has no harmonised classification for irritation / corrosion according to the Regulation (EC) No. 1272/2008 (CLP).
Self classification:
Based on the available information no additional self-classification is proposed regarding skin irritation according to the CLP and to the GHS.
For effects on eyes, the substance is classified as Eye Damage Category 1 (H318: Causes serious eye effects).
No data was available regarding respiratory irritation, however based on effects on eyes, a classification as STOT SE3 (H335: May cause respiratory irritation) is applied.
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