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EC number: 216-133-4 | CAS number: 1506-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to GLP requirements and EU method.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Cited as Directive 84/449/EEC, B.5
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
- EC Number:
- 216-133-4
- EC Name:
- 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
- Cas Number:
- 1506-02-1
- Molecular formula:
- C18H26O
- IUPAC Name:
- 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
- Details on test material:
- - Name of test material (as cited in study report): AHTN (Tonalid)
- Physical state: pure solid substance
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Healthy male young adult albino rabbits. Body weight range 2500g - 3500g obtained from ENKI konijnenfarm, Someren, The Netherlands. The animals were identified by ear marking. Animals were caged individually and did not receive hay or other extraneous material that might enter their eyes during treatment.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 gram - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 168 hours post application
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- A sample of tonalid was examined for eye irritating properties in an experiment with albino rabbits. An aliquot of 0.1 g test material was instilled in 1 eye of 3 male New Zealand White albino rabbits with no further treatment (also not rinsed). The untreated eye served as a control. The eyes were examined at 1, 24, 48 and 72 hours and at 7, 14 and 21 days if reactions persisted.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal: All animals
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 168 hours.
- Remarks on result:
- other: individual means: 1-1-0
- Irritation parameter:
- iris score
- Remarks:
- opacity
- Basis:
- animal: All animals
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: individual means: 0.67-0-0
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: All animals
- Time point:
- 24/48/72 h
- Score:
- 1.44
- Max. score:
- 3
- Reversibility:
- fully reversible within: 29 days
- Remarks on result:
- other: individual means: 1.67-1.67-1
- Irritation parameter:
- chemosis score
- Basis:
- animal: All animals
- Time point:
- 24/48/72 h
- Score:
- 1.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 168 hours
- Remarks on result:
- other: individual means: 1.67-1-1
Any other information on results incl. tables
Individual scores for 3 animals from an eye irritation test with AHTN
Time point | Cornea | Iris | Conjunctivae | Conjunctivae |
after | opacity | Redness | chemosis | |
1 hour | 0-0-0 | 0-0-1 | 2-1-2 | 2-1-2 |
24 hours | 1-1-0 | 1-0-0 | 2-2-1 | 2-1-1 |
48 hours | 1-1-0 | 1-0-0 | 2-2-1 | 2-1-1 |
72 hours | 1-1-0 | 0-0-0 | 1-1-1 | 1-1-1 |
7 days | 0-0-0 | 0-0-0 | 0-1-1 | 0-0-0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The cornea, iris, conjunctivae and chemosis scores were sufficiently assessed and the effects were fully reversible, except for some remaining redness in the conjunctivae after 7 days in 2 of the 3 animals. No effects were seen after 29 days.
- Executive summary:
AHTN (Tonalid®; purity >98%) was applied undiluted as a finely ground powder (0.1 g) to the eyes of 3 New Zealand White albino rabbits. The test substance remained in the eyes for at least 24 hours. Eye irritation was evaluated at 1, 24, 48, 72 and 168 hour post application. Two rabbits had slight corneal opacity at 24-72 hr. Slight iritis was observed in one animal at the 1 hour observation and in another animal at the 24 and 48 hour observations. A slight (1/3 animals) to moderate (2/3 animals) redness and slight (2/3) to moderate (1/3 animals) swelling of the conjunctivae was seen after 24-48 hour. After 7 days a slight redness of the conjunctivae without any other effects was still seen in two animals. All effects had cleared by 29 days.
Source: EU risk asssessment AHTN, Luxembourg, Office for Official Publications of the European Communities, ECB May 2008, p. 179
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