Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 285-503-5 | CAS number: 85114-00-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- In vivo study conducted in 2012 before the mandatory requirement for in vitro skin sensitisation test data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 2-hydroxypropyl 2-ethylhexanoate
- EC Number:
- 261-499-0
- EC Name:
- 2-hydroxypropyl 2-ethylhexanoate
- Cas Number:
- 58921-10-1
- Molecular formula:
- C11H22O3
- IUPAC Name:
- 2-hydroxypropyl 2-ethylhexanoate
- Reference substance name:
- 1-hydroxypropan-2-yl 2-ethylhexanoate
- Molecular formula:
- C11H22O3
- IUPAC Name:
- 1-hydroxypropan-2-yl 2-ethylhexanoate
- Reference substance name:
- Monoesters of 2-ethylhexanoic acid and dipropyleneglycol
- IUPAC Name:
- Monoesters of 2-ethylhexanoic acid and dipropyleneglycol
- Reference substance name:
- 1-methylethylene 2-ethylhexanoate
- EC Number:
- 301-185-3
- EC Name:
- 1-methylethylene 2-ethylhexanoate
- Cas Number:
- 93981-97-6
- Molecular formula:
- C19H36O4
- IUPAC Name:
- propane-1,2-diyl bis(2-ethylhexanoate)
- Reference substance name:
- 2-ethylhexanoic acid
- EC Number:
- 205-743-6
- EC Name:
- 2-ethylhexanoic acid
- Cas Number:
- 149-57-5
- Molecular formula:
- C8H16O2
- IUPAC Name:
- 2-ethylhexanoic acid
- Reference substance name:
- Propane-1,2-diol, propoxylated
- EC Number:
- 500-039-8
- EC Name:
- Propane-1,2-diol, propoxylated
- Cas Number:
- 25322-69-4
- IUPAC Name:
- Propane-1,2-diol, propoxylated
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Water
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 100, 50 and 25% v/v
- No. of animals per dose:
- 4 females
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- SI = 5.76, Positive
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 25% = 1.48 50% = 1.92 100% = 0.94
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 25% = 23114.85 50% = 29906.12 100% = 14639.73
Any other information on results incl. tables
There were no deaths. No signs of systemic toxicity were noted in the test or control animals during the test.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not a skin sensitiser
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
