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EC number: 938-828-8 | CAS number: 1463474-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September-October 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reported study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Acetic acid, oxo-, sodium salt, reaction products with cresol and ethylenediamine, iron sodium salts
- EC Number:
- 283-041-9
- EC Name:
- Acetic acid, oxo-, sodium salt, reaction products with cresol and ethylenediamine, iron sodium salts
- Cas Number:
- 84539-53-7
- Molecular formula:
- non specified (UVCB substance)
- IUPAC Name:
- non specified (UVCB substance)
- Details on test material:
- Appearance: red-brown powder
Batch no.: LJ 18120
Stability: at least 12 months
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga, Sulzfeld, Germany
- Age at study initiation: not indicated
- Weight at study initiation: 269-281 g (males), 194-225 g (females)
- Fasting period before study: not applicable
- Housing: 5 per sex per cage
- Diet (e.g. ad libitum): ad lib
- Water (e.g. ad libitum): ad lib
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): 50-85
- Air changes (per hr): no info
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 17 September To: 2 October 1990
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: an area of roughly 5 x 10 cm was clipped
- % coverage: not indicated
- Type of wrap if used: porous gauze dressing and Eloplast
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not indicated
- Time after start of exposure: not indicated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg was moistened sufficiently with physiological saline taking into account 72% active ingredient
- Concentration (if solution): not applicable
- Constant volume or concentration used: not applicable
- For solids, paste formed: no
VEHICLE: physilogical saline was used for sufficient moisturing - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw (taking 72% active ingredient into account) based on a RF study with 2 females
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations after patch removal: 10 min, 1, 2, 6 and 24 h, and once daily thereafter
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes - Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- None
- Clinical signs:
- other: No signs of erythema and oedema were observed.
- Gross pathology:
- Gross pathological examinations at 14 days revealed no test article-dependent findings except hair growth reduction on treated skin areas.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 is > 2000 mg/kg bw.
- Executive summary:
The study was performed according to OECD Guideline 402 (Acute Dermal Toxicity) and according to GLP standards.
The test material, EDDHMAFeK was evaluated in a limit test for its acute dermal toxicity potential in rats when administered onto the skin for 24 h at a level of 2000 mg/kg (active ingredient) to a group of 5 males and 5 females. None of the rats died. No clinical signs were observed and body weight gains were as expected. Except for hair grwoth reduction on treated skin areas, no gross abnormalities were observed at necropsy 14 days after dosing.
The acute dermal median lethal dose of EDDHMAFeK to rats was found to be greater than 2000 mg/kg bodyweight (active ingredient) or greater than 2743 mg/kg bw (test article). According to OECD-GHS, EDDHMAFeK is not classified.
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