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EC number: 203-544-9 | CAS number: 108-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Four Sprague-Dawley derived Cox male rats were exposed to 1-NP vapors in a 360 liter air chamber for six hours at various concentrations of 1-NP. At the end of the six hour exposure time, the rats were sacrificed, the livers excised and the livers analyzed for 1-NP content.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- 1-nitropropane
- EC Number:
- 203-544-9
- EC Name:
- 1-nitropropane
- Cas Number:
- 108-03-2
- Molecular formula:
- C3H7NO2
- IUPAC Name:
- 1-nitropropane
- Details on test material:
- Commercial grade 1-Nitropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley derived Cox rats
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Rats were exposed to 1-NP vapors in a 360 liter air chamber for six hours at various concentrations of 1-NP. The chamber was controlled by rotameters and monitored with a Miran Infra-red Gas Analyzer. The flow rate was such that ten complete changes of air occurred each hour.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The chamber was monitored with a Miran Infra-red Gas Analyzer.
- Duration of treatment / exposure:
- 6 hours
- Frequency of treatment:
- Once
- Post exposure period:
- Some tests were made to determine the duration of 1-NP residue in the liver tissue of rats after exposure to 1200 ppm commercial grade 1-NP in an air inhalation chamber for 6 hours. The high level was chosen because 1200 ppm is near the LC 50 for 1-NP.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1000, 1100, 1200 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4 males/exposure
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Some tests were made to determine the concentration of 1-nitropropane (1-NP) in the liver tissue of male rats after exposure to commercial grade 1-NP in an air inhalation chamber. Four Sprague-Dawley derived Cox male rats 160-180 grams of weight each, were exposed to 1-NP vapors in a 360 liter air chamber for six hours at various concentrations of 1-NP. The chamber was controlled by rotameters and monitored with a Miran Infra-red Gas Analyzer. The flow rate was such that ten complete changes of air occurred each hour. At the end of the six hour exposure time, the rats were sacrificed, the livers excised,and the livers analyzed for 1-NP content. The tissues were homogenized with sulfosalicylic acid to precipitate the protein and the homogenate was azeotropically distilled to remove the 1-NP from impurities. Two fractions of 5 ml each were collected. The fractions were analyzed for 1-NP by gas chromatography using a flame ionization detector.
Some tests were made to determine the duration of 1-NP residue in the liver tissue of rats after exposure to 1200 ppm commercial grade 1-NP in an air inhalation chamber for 6 hours. The high level was chosen because 1200 ppm is near the LC 50 for 1-NP.
Examinations
- Examinations:
- At the end of the six hour exposure time, the rats were sacrificed, the livers excised,and the livers analyzed for 1-NP content. The tissues were homogenized with sulfosalicylic acid to precipitate the protein and the homogenate was azeotropically distilled to remove the 1-NP from impurities. Two fractions of 5 rnl each were collected. The fractions were analyzed for 1-NP by gas chromatography using a flame ionization detector.
Results and discussion
- Details on results:
- The 1-NP content should increase as the level in the chamber increases. It is estimated that if 700 ppm or lower was used in the chamber, no 1-NP would accumulate in the liver.
The data indicate that after a 6 hour inhalation exposure to 1-NP at 1200 ppm, the liver accumulates 50 ppm 1-NP, The 1-NP increased at 2 hours, then began to decrease. It is estimated that the 1-NP would disappear after 8-10 hours.
Applicant's summary and conclusion
- Conclusions:
- The 1-NP content should increase as the level in the chamber increases. It is estimated that if 700 ppm or lower was used in the chamber, no 1-NP would accumulate in the liver. The data also indicate that after a 6 hour inhalation exposure to 1-NP at 1200 ppm, the liver accumulates 50 ppm 1-NP, The 1-NP increased at 2 hours, then began to decrease. It is estimated that the 1-NP would disappear after 8-10 hours.
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