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EC number: 933-047-9 | CAS number: 53880-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- June 25, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- The protocol for this study is executed according to the ICCVAM Test Method Evaluation Report: Appendix G: ICCVAM Recommended Protocol for Future Studies Using the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) Test method, November 2006.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Oligomerisation products of 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate and butan-1-ol and pentan-1-ol and 2-ethylhexan-1-ol, allophanate type
- EC Number:
- 933-047-9
- Cas Number:
- 53880-05-0
- Molecular formula:
- not applicable (UVCB substance)
- IUPAC Name:
- Oligomerisation products of 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate and butan-1-ol and pentan-1-ol and 2-ethylhexan-1-ol, allophanate type
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- other: Assessment of the irritant/corrosive potential of the test substance by observing its effect on the extra-embryonal blood vessel system (e.g. haemorrhage, vessel lysis, coagulation) of the fertile 8 days incubated chicken egg.
- Details on test animals or tissues and environmental conditions:
- The analysis model used for this study is the fertile Lohmann Brown hen egg (Brinkschulte Josef GmbH & Co.KG, 48308 Senden, Germany), which is incubated for 8 days before test item application.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: as negative control: physiological saline solution (0.9 % NaCl, 300 µL)
- Details on study design:
- After 7 days of incubation (37.5 °C, relative humidity 63 %) in an incubator with an automatic rotating device, all eggs were candled in order to discard those that were defect and to mark the air bubble. The eggs were replaced into the incubator with the large end upward but not rotated, thus ensuring accessibility to the CAM region. At day 8 of incubation the sections marked for the air bubble were sawed out of the shell. The inner membrane was moistened with NaCl 0.9 % and carefully removed with forceps. Only eggs with normally developed embryos and blood vessel systems were used for testing. A 100 % concentration (300 mg) is tested on the chorioallantoic membrane (HET-CAM) of a chicken embryo. 4 eggs each were used for negative and positive controls and for the test substance.
As positive control 1 % sodium dodecyl sulfate was applied.
Observations of effects to the blood vessels, albumen or embryo over a period of 300 seconds after substance application are determined for each single egg. The time to the appearance of each of the observations mentioned above has been monitored and recorded. If no effect appeared during the observation period of 300 seconds (observation = 0) the result was assigned as negative for the related endpoint, and the factor set to 0 for this endpoint when calculating the Irritation Score (IS).
Formula for calculation of IS:
IS = 5 x (301-sec H)/300 + 7 x (301- sec L)/300 + 9 x (301- sec C)/ 300
H= observed start in seconds of haemorrhage reactions; L= observed start in seconds of vessel lysis, strong haemorrhage; C= observed start in seconds of blood - coagulation, albumen - coagulation
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- 0
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
result with test substance, 300 mg
egg | effect | effects detected after [sec] |
IS | |||
1 |
1 | >300 | 0 | |||
2 | >300 | 0 | ||||
3 | >300 | 0 | ||||
2 |
1 | >300 | 0 |
|||
2 | >300 | 0 | ||||
3 | >300 | 0 | ||||
3 | 1 | >300 | 0 | |||
2 | >300 | 0 | ||||
3 | >300 | 0 | ||||
4 | 1 | >300 | 0 | |||
2 | >300 | 0 | ||||
3 | >300 | 0 |
effects: 1 = vasodilatation, slight haemorrhage (H), 2 = vessel lysis, strong haemorrhage (L), blood-coagulation, albumen-coagulation (C)
The test substance induced no irritant effects to the chorioallantoic membrane of hen eggs under the conditions of this assay.
The positive and negative controls were functional.
Applicant's summary and conclusion
- Interpretation of results:
- other: no corrosive property
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