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EC number: 242-616-4 | CAS number: 18835-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1992-06-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted according to GLP and followed guidelines (OECD 401, U.S. EPA/TSCA) that were acceptable at the time the study was performed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hexadec-1-ene
- EC Number:
- 211-105-8
- EC Name:
- Hexadec-1-ene
- Cas Number:
- 629-73-2
- IUPAC Name:
- hexadec-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Gulftene 16
- Test substance: C16 alpha olefin
- Physical state: Liquid, colourless, low viscosity
- Composition of test material, percentage of components:
100% Gulftene 16
(93.0% 1-hexadecene, 2% 2-Ethyl-1-Tetradecene, 2% 2-Butyl-1-Dodecene, 2% 2-Hexyl-1-Decene, and 1% Hexadecene-N)
- Storage condition of test material: Stored in room temperature in a chemical storage cabinet
Constituent 1
Test animals
- Species:
- other: rat, albino
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague-Dawley, Incorporated
- Age at study initiation: 7 to 13 weeks
- Weight at study initiation: 200 to 299 grams
- Fasting period before study: 18 hours
- Housing: Separated by sex, 5 per cage, housed in wire floor cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68 to 74
- Humidity (%): 45 to 56
- Photoperiod (hrs dark / hrs light): 12 hrs dark/ 12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100% Gulftene 16 (93% hexadecene-1)
MAXIMUM DOSE VOLUME APPLIED: 10 g/kg - Doses:
- 5 g/kg and 10 g/kg; individual doses were adjusted according to rat body weight.
10 g/kg: (Dose did not exceed more than 1.0 millilitre per 100 grams of body weight.) This dose level was split into two administrations, with one hour between doses. - No. of animals per sex per dose:
- 5 male and 5 female dosed at 10 g/kg
5 male and 5 female dosed at 5 g/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 1, 2 and 14 days (additional observations were made is suggested by Neurotoxicologist.)
- Frequency of observations and weighing: Weighing occurred at 7 and 14 days after dosing.
- Necropsy of survivors performed: Yes - Statistics:
- None reported.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- 10 g/kg dose - 2/5 males and 2/5 females died
No lethality was observed at 5 mg/kg bw in either sex. - Clinical signs:
- other: Several reported clinical signs were linked to excessive excretion of the compound including red extremities, unkempt appearance, discharge on perineal fur, greasy wet perineal fur and hindlimb regions, and alopecia and scabs on the perineal fur, hind lim
- Gross pathology:
- Necropsy revealed discoloration in lungs, intestines (with distention), liver (1 animal) and kidneys in rats that died or were sacrificed during the study period. Surviving animals had no remarkable gross lesions. No lesions were found in tissues taken to evaluate neurotoxicity (brains, spinal cords, sciatic nerves and pituitaries.
- Other findings:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Not classified because LD50 is greater than the requirements for a Category 4 toxicant (2000 mg/kg) Criteria used for interpretation of results: EU
- Conclusions:
- No histopathological signs of lesions were found in the central or peripheral nervous system. Clinical signs were not considered to be related to the irritation of the abdominal and hindlimb areas. Based on these results, Gulftene 16 did not appear to produce primary neurotoxicant effect.
- Executive summary:
In an acute oral toxicity study, two groups of 10 (male and female) Sprague-Dawley albino rats, 7 to 13 weeks of age, which had fasted for 18 hours, were given a single oral dose of Gulftene 16 at 10 g/kg or 5 g/kg. These animals were observed for a total of 14 days.
There was no treatment related clinical signs, necropsy findings or changes in body weight. The oral LD50 was determined to be 10 g/kg bw in both males and females.
This study received a Klimisch score of 1 and is classified as "reliable without restriction" because it was conducted according to GLP and followed guidelines (OECD 401, U.S. EPA/TSCA) that were acceptable at the time the study was performed.
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