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Diss Factsheets
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EC number: 931-895-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Hypothesis for read-across: Cobalt dihydroxide and nickel dihydroxide are the main components of the target UVCB-substance, and considered the major drivers for adverse effects based on its properties and relative quantity in the substance. For read-across purpose, data from the constituents (cobalt dihydroxide and nickel dihydroxide) of the target UVCB-substance is used in the REACH registration. A well described guideline study for cobalt dihydroxide.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cobalt dihydroxide
- EC Number:
- 244-166-4
- EC Name:
- Cobalt dihydroxide
- Cas Number:
- 21041-93-0
- Molecular formula:
- CoH2O2
- IUPAC Name:
- cobalt(2+) dihydroxide
- Details on test material:
- No further details given.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not stated
- Age at study initiation: "young"
- Weight at study initiation:200-300g
- Fasting period before study: yes, no period given
- Housing: not stated
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: not stated
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 250, 500, 1000, 2000, 4000, 8000mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no - Statistics:
- nmot reported
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 060 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 680 - 1 660
- Sex:
- male/female
- Dose descriptor:
- LD100
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- yes
- Clinical signs:
- other: diarrhea, ruffled fur, debilitation
- Gross pathology:
- not conducted
Any other information on results incl. tables
Cobalt hydrate powder
fasted male and female albino rats
weights 200 -300 grams
vehicle: polypropylene glycol
Dose level |
No. animals |
Number of days and deaths |
total |
|
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
survivals |
Deaths |
||
250 |
5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
0 |
500 |
5 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5 |
0 |
1000 |
5 |
|
|
|
|
1 |
|
|
|
1 |
1 |
|
|
|
|
2 |
3 |
2000 |
5 |
|
|
|
|
1 |
1 |
|
|
1 |
1 |
|
|
|
|
1 |
4 |
4000 |
5 |
|
|
|
4 |
|
|
|
|
|
1 |
|
|
|
|
0 |
5 |
8000 |
5 |
|
2 |
|
2 |
1 |
|
|
|
|
|
|
|
|
|
0 |
5 |
Justification for read-across: Cobalt dihydroxide and nickel dihydroxide are the main components of the target UVCB-substance, and considered the major drivers for adverse effects based on its properties and relative quantity in the substance. For read-across purpose, data from the constituents (cobalt dihydroxide and nickel dihydroxide) of the target UVCB-substance is used. According to section 1.5, annex XI of regulation (EC) 1907/2006, such studies do not need to be conducted, since adequate data from structurally analogous substances are available. Therefore read-across from these compounds is justified.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The following LD50 value was determined for cobalt dihydroxide:
LD50 (combined male and female rats): 1060 mg/kg bw
According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is classified as harmful.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is classified as Category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.