Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-297-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: scientific assessment based on original toxicological data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
- Principles of method if other than guideline:
- Comparative assessment of the toxicologic properties of HDI Trimer asym. (HDI oligomers, iminooxadiazindione, CAS-no. 28182-81-2) and HDI Trimer (HDI oligomers, isocyanurate, CAS-no. 28182-81-2). Document for verification of read-across.
Test material
- Reference substance name:
- HDI oligomers, iminooxadiazindione
- IUPAC Name:
- HDI oligomers, iminooxadiazindione
Constituent 1
Results and discussion
- Details on results:
- For details on results see attached document.
Applicant's summary and conclusion
- Conclusions:
- Comparative assessment of the toxicologic properties of HDI Trimer asym. (HDI oligomers, iminooxadiazindione, CAS-no. 28182-81-2) and HDI Trimer (HDI oligomers, isocyanurate, CAS-no. 28182-81-2). Document for verification of read-across.
- Executive summary:
Cited from summary of report: "Desmodur® N3300 & Desmodur® XP 2410 are both alicyclic, HDI-based homopolymers. Previous studies addressing the acute pulmonary irritation potency of the aerosol have shown that the principle mode of action is confined to ‘pulmonary irritation’ which resembles the site of the initial deposition of aerosol. Comparative acute and subchronic 13-week inhalation studies have demonstrated that the subchronic NOAEC is contingent on the acute NOAEC. The latter can be best and most sensibly quantified by systematic studies addressing the time-course and concentration-response relationship of protein in bronchoalveolar lavage fluid (BALF). The scientific rationales have been published in detail elsewhere (Pauluhn, Toxicol Sci. 58: 173-181, 2000; Inhalation Toxicology 14: 287-301, 2002; Archives of Toxicology 78: 243-251, 2004, Inhalation Toxicology 16: 159-175, 2004; Journal of Applied Toxicology 24: 231-247, 2004; Pauluhn and Mohr, Inhalation Toxicology 13: 513-532, 2001). With regard to species-sensitivity the rat appears to be the species of choice (Pauluhn, Toxicology. 247:33-45, 2008). The comparison of the exposure characteristics of both Desmodur® N3300 & Desmodur® XP 2410 was essentially similar. The time-course of BAL-protein changes as well as the concentration-response relationship were also similar. The increase in BAL-protein at the lowest tested concentration of 3-4 mg/m³ as well as the extrapolation non-irritation threshold concentration (2 mg/m³) were essentially identical. At about 10-times higher concentrations Desmodur® XP 2410 aerosol appeared to be slightly more irritant. In summary, the basic toxicological mechanisms and toxic potencies of Desmodur® N3300 & Desmodur® XP 2410 appear to be indistinguishable. As long as subtle differences exist they appear within of the resolution of this bioassay. Due to the confluence of critical toxicity data in the MOAEC-range it does not appear to scientifically justified to consider the toxic potencies of Desmodur® N3300 & Desmodur® XP 2410 to be different. Accordingly, due to animal welfare reasons as well the availability of data the inhalation toxicity data generated for Desmodur® N3300 should also be valid for Desmodur® XP 2410."
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.