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EC number: 207-529-8 | CAS number: 479-27-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch number: 160705
Date of receipt: 2016-09-23
Expiry date: 2018-09-22 - Water solubility:
- 0.78 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 3.316 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 9.1
- Water solubility:
- 0.756 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 3.369 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 8.3
- Water solubility:
- 0.779 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 3.664 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 8.1
- Key result
- Water solubility:
- 0.772 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- >= 8.1 - <= 9.1
- Remarks on result:
- other: mean value
- Details on results:
- The relative standard deviation between the single determinations is < 15 %.
Remark: In a preliminary test the concentration found was 640 mg/L. Therefore the concentration for the main test was set to approx. 3200 mg/L. This corresponds to 5 times the concentration found in the pretest. - Conclusions:
- Water solubility of 1,8-naphthylendiamine was determined to be 0.772 g/L (at 20 °C).
- Executive summary:
The water solubility of 1,8-naphthylendiamine in demineralized water was determined according to OECD 105 and OPPTS 830.7840. In a preliminary test, the water solubility of the test item was found to be > 10^-2 g/L (approximately 640 mg/L). Therefore, the shake flask method was chosen for the determination of the water solubility. For the main test, a quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and is kept in the temperature controlled water bath for another 24 h. After phase separation by centrifugation (20 minutes, 9000 rpm, 20 °C), the concentration of 1,8-naphthylenediamine in aqueous test solutions was determined by HPLC-analysis with UV-detection.
Water solubility of 1,8-naphthylendiamine was determined to be 0.772 g/L (at 20 °C). The relative standard deviation between the single determinations was < 15 %. The validity criteria have been met.
Reference
The validity criteria were met.
Description of key information
The water solubility of the test item 1,8-naphthylendiamine in demineralized water was determined with the shake flask method at 20 °C according to OECD 105 and OPPTS 830.7840. The concentration of 1,8-naphthylenediamine in aqueous test solutions was determined by HPLC analysis with UV detection. Water solubility of 1,8-naphthylendiamine was determined to be 0.772 g/L (at 20 °C). The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.
Key value for chemical safety assessment
- Water solubility:
- 0.772 g/L
- at the temperature of:
- 20 °C
Additional information
In a preliminary test, the water solubility of the test item was found to be > 10^-2 g/L (approximately 640 mg/L). Therefore, the shake flask method was chosen for the determination of the water solubility. For the main test, a quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and is kept in the temperature controlled water bath for another 24 h. After phase separation by filtration with a disposable syringe filter and/or centrifugation (20 minutes, 9000 rpm, 20 °C), the concentration of 1,8-naphthylenediamine in aqueous test solutions was determined by HPLC-analysis with UV-detection.
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