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EC number: 235-183-8 | CAS number: 12124-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Principles of method if other than guideline:
- Method: other: method in agreement with "concepts of the Dutch Standardisation Institute"
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- not specified
- Test organisms (species):
- Poecilia reticulata
- Dose descriptor:
- LC50
- Effect conc.:
- 180 - 225 mg/L
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 - 100 mg/L
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Dutch Standardisation Organisation (1980; NEN 6501, 6502, 6504 & 6506)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- no
- Details on sampling:
- not stated
- Vehicle:
- no
- Details on test solutions:
- Criteria Details
Source Distilled water containing additional salts
Salinity Levels of dissolved ions (ppm by weight):
Calcium 5.9
Magnesium 1.5
Sodium 11.3
Bicarbonate 20.0
Chloride 12.1
Sulfate 11.2
Nitrate 0.7
Details are from Alabaster et al. (1965) as referenced in Canton J.H. et al. (1976) and Canton J.H. et al. (1983).
Hardness 20 ppm as CaCO3
pH Not stated
Oxygen content Not stated
Conductance <10 mhos/cm3
Holding water different from dilution water Not stated - Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- Species/strain Poecilia reticulata
Source Standardised laboratory cultures
Wild caught No
Age/size 8-9 months - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 124 d
- Post exposure observation period:
- no further details
- Hardness:
- no details
- Test temperature:
- 23 degree C
- pH:
- not stated
- Dissolved oxygen:
- not stated
- Salinity:
- not stated
- Nominal and measured concentrations:
- 0, 7.8, 78, 390, 780, 3900 and 7800 mg Br-/L
- Details on test conditions:
- Photoperiod
14 h photoperiod daily
Test temperature
23 ± 2 °C - Reference substance (positive control):
- no
- Duration:
- 124 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Duration:
- 124 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Details on results:
- For the top three dose groups, during the first 5 weeks of exposure, a few cases of prematures were born and the newborn fish were immobile or
dead. After this period no reproduction occurred at all and, as the animals deteriorated, all fish in these groups were killed after about 10 weeks of
exposure. In the 390 mg/L dose group the birth of prematures was noted in two cases. In lower doses only the number of newborn fish was reduced.
In the histopathological evaluations, fish showed three major lesions, namely thyroid hyperplasia, myopathy and regressive changes in the female
reproductive tract. Thyroid hyperplasia was noted in the groups exposed to 78 mg Br-/L and above. Myopathy was noted with high incidence in the
two highest dose groups and present in a few cases at 78 to 780 mg Br-/L.
In the groups exposed to 390, 780, 3900 or 7800 mg Br-/L a marked reduction in the number of foetuses was noted, along with regressive or degenerative changes of the reproductive tract, such as ovarian atrophy, cystic follicles and the occasional resorptions of an advanced stage foetus. No treatment-related changes were observed in the male reproductive organs.
NOECs:
Mortality: ≥ 7800 mg Br-/L
Mortality and behaviour: 78 mg Br-/L
Reproduction: 7.8 mg Br-/L - Results with reference substance (positive control):
- no further details
- Reported statistics and error estimates:
- not stated
- Validity criteria fulfilled:
- no
- Conclusions:
- Male and female Poecilia reticulata were exposed to sodium bromide (concentration ranging from 7.8 to 7800 mg Br-/L) in test waters for 124 days in a semi-static toxicity to reproduction test. Observations of mortality, abnormal behaviour and reproductive effects along with histopathological studies were used to determine the NOEC value.
Individual mortality and sublethal effects data were not given. Histopathological changes were noted at concentrations of 78 mg Br-/L and above. The NOEC was found to be 7.8 mg Br-/L (10.0 mg/L NaBr) - Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Method: other: Dutch Standardisation Organisation (1980; NEN 6501, 6502, 6504 & 6506)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- no
- Test organisms (species):
- Oryzias latipes
- Duration:
- 34 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Duration:
- 34 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Method: other: Dutch Standardisation Organisation (1980; NEN 6501, 6502, 6504 & 6506)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- no
- Test organisms (species):
- Poecilia reticulata
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.032 g/L
- Nominal / measured:
- nominal
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.1 g/L
- Nominal / measured:
- nominal
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- no
- Test organisms (species):
- Oryzias latipes
- Test type:
- semi-static
- Duration:
- 40 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Duration:
- 40 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 4 (not assignable)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- not specified
- Test organisms (species):
- Poecilia reticulata
- Duration:
- 31 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.76 mg/L
- Conc. based on:
- other: bromide ions
- Basis for effect:
- other: histopathology
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 4 (not assignable)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- not specified
- Test organisms (species):
- Oryzias latipes
- Duration:
- 31 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 140 mg/L
- Conc. based on:
- other: Bromide ions
- Basis for effect:
- other: Histopathology
- Duration:
- 93 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 140 mg/L
- Conc. based on:
- other: Bromide ions
- Basis for effect:
- other: Histopathology
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1991
- Reliability:
- 4 (not assignable)
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- not specified
- Test organisms (species):
- Poecilia reticulata
- Duration:
- 31 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.76 mg/L
- Conc. based on:
- other: Bromide ions
- Basis for effect:
- other: Histopathology
- Duration:
- 93 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 24.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Bromide ions
- Basis for effect:
- other: Histopathology and general toxicity
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1991
- Reliability:
- 4 (not assignable)
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Test organisms (species):
- Oryzias latipes
- Duration:
- 31 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 140 mg/L
- Conc. based on:
- other: Bromide ions
- Basis for effect:
- other: Histopathology
- Duration:
- 93 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 248 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: Bromide ions
- Basis for effect:
- other: Histopathology and general toxicity
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- no
- Test organisms (species):
- Poecilia reticulata
- Duration:
- 3 mo
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Duration:
- 3 mo
- Dose descriptor:
- LOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Details on results:
- Test result is equivalent to: NOEC = 7.76 mg(Br-)/L for the bromide ion
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide. - Analytical monitoring:
- yes
- Test organisms (species):
- Oryzias latipes
- Duration:
- 3 mo
- Dose descriptor:
- NOEC
- Effect conc.:
- < 180 mg/L
- Duration:
- 3 mo
- Dose descriptor:
- LOEC
- Effect conc.:
- <= 180 mg/L
- Nominal / measured:
- nominal
Referenceopen allclose all
Test result is equivalent to: NOEC = 7.76 mg(Br-)/L for the bromide ion |
Test result is equivalent to: NOEC = 7.76 mg(Br-)/L for the bromide ion |
Test result is equivalent to: NOEC = 248 mg(Br-)/L for the bromide ion |
The 28 day NOEC was found to be 0.025 g Br-/L (0.032 g/L NaBr) based on mortality and behaviour. The NOEC based on mortality was 2.5 g Br-/L (3.2 g/L NaBr) and the NOEC based on growth was 0.25 g Br-/L (0.32 g/L NaBr).
Test result is equivalent to: NOEC = 248 mg(Br-)/L for the bromide ion |
NOEC (general toxicity) = 32 mg/L (equivalent to 24.8 mg(Br-)/L) |
NOEC (general toxicity) = 320 mg/L (equivalent to 248 mg(Br-)/L) |
NOEC (general toxicity) = 32 mg/L (equivalent to 24.8 mg(Br-)/L) 93 days:NOEC (general toxicity) = 32 mg/L (equivalent to 24.8 mg(Br-)/L) |
31 days:NOEC (general toxicity) = 320 mg/L (equivalent to 248 mg(Br-)/L) 93 days:NOEC (general toxicity) = 320 mg/L (equivalent to 248 mg(Br-)/L) |
Description of key information
Male and female Poecilia reticulata were exposed to sodium bromide in a semi-static toxicity to reproduction test. Observations of mortality, abnormal behaviour and reproductive effects along with histopathological studies were used to determine the NOEC value. Histopathological changes were noted at concentrations of 78 mg Br-/L and above. The lowest NOEC for the sodium bromide for reproductive effects in fish is 10 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 10 mg/L
Additional information
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.
Male and female Poecilia reticulata were exposed to sodium bromide in a semi-static toxicity to reproduction test. Observations of mortality, abnormal behaviour and reproductive effects along with histopathological studies were used to determine the NOEC value. Histopathological changes were noted at concentrations of 78 mg Br-/L and above. The lowest NOEC for the sodium bromide for reproductive effects in fish is 10 mg/L from the study by Canton et al., 1983. An additional study (Wester P.W.et al., 1988;) also found the NOEC based on histopathological changes to be 10 mg/L but the study did not evaluate the reproductive effects of the test substance. Organs affected included the thyroid, gonads, skeletal muscle and mesenteric arteries.
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