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EC number: 298-265-2 | CAS number: 93783-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity
LD50 (male) = 395 mg/kg, equivalent to
177.8 mg/kg a.i..
LD50 (female) = 275 mg/kg, equivalent to 124 mg/kg a.i..
Acute dermal toxicity
LD0 = 2000 mg/kg, equivalent to 1732 mg/kg a.i.
LD50 > 2000 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 124 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Oral route
No data on acute oral toxicity was available on target substance. Therefore, available data on Similar Substance 01 and 02, i.e. different salifications of target substance, was used. Details on the read across process are reported in section 13.
Available study with higher reliability was selected as key study and used for decision on classification; supporting studies confirmed such result.
In all studies, rats of both sexes were dosed by gavage and observed for symptoms for 14 days. Based on mortality, LD50 values between 50 and 300 mg/kg were determined.
Clinical symptoms of intoxication, in terms of decreasing general condition, nausea, abdominal / lateral position, sedation, cramps and gasping breathing were seen in all studies. Non-specific damage of the gastrointestinal tract was also seen as main finding in all dead animals upon examinantion.
Tested doses were:
- key study with Similar Substance 01: 200, 350, 500, 1000 mg/kg
- supporting study with Similar Substance 01: 50, 100, 200, 500, 800 mg/kg (M); 50, 100, 200, 250, 310 mg/kg (F)
- supporting study with Similar Substance 02: 100, 160, 200, 225 mg/kg
In the key study, a NOAEL of 200 mg/kg (90 mg/kg a.i.) was established only in male rats. In supporting studies, no clinical symptoms were noted at a dose of 50 mg/kg with Similar Substance 01, i.e NOAEL = 50 mg/kg (28.7 mg/kg a.i.), and at a dose of 100 mg/kg with Similar Substance 02, i.e NOAEL = 100 mg/kg (38 mg/kg a.i.).
Dermal route
Acute dermal toxicity was assessed in male
and female rats based on data on target substance. Test substance was
applied in semiocclusive way at 1000 and 2000 mg/kg for 24 hours;
observation was continued for 14 days. No mortality was seen.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), table 3.1.1, acute toxicity hazard categories and acute toxicity estimates (ATE) defining the respective categories:
For acute toxicity by oral route:
category 1: ATE <= 5 mg/kg bw
category 2: 5 < ATE <= 50 mg/kg bw
category 3: 50 < ATE <= 300 mg/kg bw
category 4: 300 < ATE <= 2000 mg/kg bw
For acute toxicity by dermal route:
category 1: ATE <= 50 mg/kg bw
category 2: 50 < ATE <= 200 mg/kg bw
category 3: 200 < ATE <= 1000 mg/kg bw
category 4: 1000 < ATE <= 2000 mg/kg bw
Based on available information, target substance is classified as Category 3 (H301) for acute oral toxicity, while it is not classified for acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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