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Diss Factsheets
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EC number: 267-023-8 | CAS number: 67762-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Based on the available information it can be concluded that the substance fulfills the P criterion, but not the B/vB nor the T criteria, and hence can not be assessed as PBT or vPvB.
Persistence
While the registered substance was not readily biodegradable in the OECD 301B test, it did show 45% degradation in 28 days. It is assessed as P but not vP.
BIOWIN modeling of a representative structure of the registered substance shows the following results:
• BIOWIN6 (MITI non-linear model): 0.6479
• BIOWIN3 (ultimate survey model): 2.7198 (weeks-months)
• Ready biodegradability prediction: No
These values indicate that the registered substance may be potentially P but not vP.
This is further borne out by Fugacity Level 3 modelling (EPI Suite v4.00-4.11) of a representative structure of the TS, which shows that it is expected to partition preferentially into soil (82.5 %) and then water (17.5 %), with estimated half-lives of 75 and 37.5 days respectively, which are both below the respective Annex XIII criteria of 120 and 40 days respectively. The use of multi-media modelling is allowed in ECHA guidance on PBT/vPvB assessment (Chapter R.11: PBT/vPvB assessment, v3.0 (June 2017).
Bioaccumulation
Two log Kow studies have been conducted on Alkenes, C15-18 α-, sulfurized conducted according to OECD 117. In the first study, the log Kow was determined to be >9.4; the highest log Kow of reference standards (1-phenyltridecane) established by HPLC at the time. In the second study, 1-phenyltetradecane was also used as a reference standard, and has a log Kow of 10. The log Kow was determined to be greater than this reference standard. Therefore, the log Kow of Alkenes, C15-18 α-, sulfurized was established as >10. ECHA Chapter R.11: PBT/vPvB assessment states: "The aquatic BCF of a substance is probably lower than 2000 if the calculated log Kow is higher than 10”. On this basis, the BCF of Alkenes, C15-18 α-, sulfurized is considered to be <2000.
ECHA Chapter R.11: PBT/vPvB assessment states “From one study of a diverse set of substances it appeared that for compounds with a DMAXaver larger than 1.7 nm the BCF value will be less than 2000”. DMAXaver for representative structures, with the exception of one structure, were >1.7 nm. Therefore, it can be considered that, based on molecular diameter, they will not bioaccumulate. The other structure has a DMAXaver value of 1.6 nm. This is very slightly below the threshold. However, it should be noted that this is not an ‘absolute’ limit, and therefore, it is considered that bioaccumulation of this structure is unlikely.
However, further investigation was conducted using QSARs. QSARs indicate that all of the representative structures are not bioaccumulative (BCFs <10 L/kg).
The toxicity data are also experimental indicators for hinderance of uptake of this substance. A range mammalian toxicity studies have been performed, crucially, including an OECD 408 90-day oral toxicity study in rodents. In all studies, no effects were seen at the maximum dose tested (1000 mg/kg bw/day). This lack of effects is indicative of very low uptake of the test substance. Therefore, it can be concluded that bioaccumulation is unlikely to occur.
Therefore, the substance is not considered B or vB.
Toxicity
A chronic fish study in fathead minnow (Pimephales promelas) in accordance with OECD 210, "Fish, Early-Life Stage Toxicity Test”. Over the duration of the test there were no significant mortalities or sub-lethal effects of exposure resulting from the exposure of the early-life stages of fathead minnow (Pimephales promelas) larvae up to a test concentration of 100 mg/L loading rate WAF. A 33-day EL10 of >100 mg/L WAF was determined.
A chronic invertebrate study was performed with Daphnia magna in accordance with OECD 211, "Daphnia magna Reproduction Test". Due to the low aqueous solubility and complex nature of the test item, the test medium was prepared as a Water Accommodated Fraction (WAF). A 21-day EL10 of >100 mg/L was established.
Therefore, the test substance is not T based on EC10/NOEC values >0.01 mg/L.
There was no evidence of toxicity at all three trophic levels was observed in short-term aquatic studies up to 100 mg/L, i.e. E(L)L50s are > 100mg/L.
The substance is not classified with regard carcinogenicity (category 1 or 2), mutagenicity (category 1 or 2) or toxicity to reproduction (category 1, 2 or 3) according to Directive 67/548/EEC or carcinogenicity (category 1A or 1B), germ cell mutagenicity (category 1A or 1B) or toxicity to reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008.
There is no evidence of chronic toxicity, as identified by the classifications T, R48 or Xn, R48 according to Directive 67/548/EEC or specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008.
Therefore, the substance is not considered T.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.