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EC number: 200-795-6 | CAS number: 73-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1980
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study in Japanese with brief English summary
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological studies on N-Acetyl-L-Tryptophan. II. Subacute toxicity in rats
- Author:
- Kawaguchi Y, Kotera K & Takemoto Y
- Year:
- 1 980
- Bibliographic source:
- Iyakuhin Kenkyu 11, 646-665
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- L-tryptophan
- EC Number:
- 200-795-6
- EC Name:
- L-tryptophan
- Cas Number:
- 73-22-3
- Molecular formula:
- C11H12N2O2
- IUPAC Name:
- L-tryptophan
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500, 1000 or 2000 mg/kg bw/d
- No. of animals per sex per dose:
- no data
Examinations
- Observations and examinations performed and frequency:
- Body weight, body weight gain, food and water consumption, haematology, clinical biochemistry, urine analysis
- Sacrifice and pathology:
- absolute and relative organ weights of relevant organs, histopathological examination
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In the L-tryptophan dosed animals, death, depression of motor activity, inhibition of body weight gain, reduction of food consumption, increase of water consumption and urinary volume, and piloerection were observed in the both sexes given >= 1000 mg/kg bw/d. Serum biochemistry showed elevation of GOT activity in both of the males given 2000 mg/kg bw/d and in females given above 1000 mg/kg bw/d. Elevation of ALP activity was noted and liver and kidney weights increased in females at all doses. In the histopathological examination, hepatocyte hypertrophy as well as atrophy of thymus was observed in animals at above 1000 mg/kg bw/d.
- Executive summary:
In the L-tryptophan dosed animals, death, depression of motor activity, inhibition of body weight gain, reduction of food consumption, increase of water consumption and urinary volume, and piloerection were observed in the both sexes given >= 1000 mg/kg bw/d. Serum biochemistry showed elevation of GOT activity in both of the males given 2000 mg/kg bw/d and in females given above 1000 mg/kg bw/d. Elevation of ALP activity was noted and liver and kidney weights increased in females at all doses. In the histopathological examination, hepatocyte hypertrophy as well as atrophy of thymus was observed in animals at above 1000 mg/kg bw/d.
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