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EC number: 914-172-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
- Short-term toxicity to fish (Reliability 2, GLP):LC50= 100 mg/L substance tested = tripotassium trihydrogen diphosphate dihydrate
- Short-term toxicity to daphnia (Reliability 2, GLP):LC50= 100 mg/L substance tested = tripotassium trihydrogen diphosphate dihydrate
- Algal growth inhibition study (Reliability 2, GLP):EC50= 100 mg/L substance tested = tripotassium trihydrogen diphosphate dihydrate
- ASRI: (Reliability 2, GLP):EC50= 1000 mg/L , substance tested = dipotassium hydrogenorthophosphate
- Assessment factors:
- Lowest value from short-term studies: 100 mg/L
- Assessment factors:
- Lowest value from short-term studies: 100 mg/L
- Assessment factors:
- Lowest value from short-term studies: 100 mg/L
Derivation of PNECs for sodium, potassium, calcium and magnesium orthophosphates:
READ-ACROSS
The following substances are considered to be similar enough to facilitate read-across for aquatic toxicity and subsequently for the derivation of PNEC’s:
Sodium and potassium orthophosphates:
Sodium dihydrogenorthophosphate
Disodium hydrogen phosphate
Trisodium orthophosphate
Potassium dihydrogenorthophosphate
Dipotassium hydrogenorthophosphate
Tripotassium orthophosphate
Potassium pentahydrogen bis(phosphate)
Tripotassium trihydrogen diphosphate dihydrate.
Calcium and magnesium orthophosphates:
Calcium bis(dihydrogenorthophosphate)
Calcium hydrogen orthophosphate
Tricalcium bis(orthophosphate)
Tricalcium phosphate
Magnesium hydrogenorthophosphate
Trimagnesium bis(orthophosphate)
Magnesium bisdihydrogenorthophosphate
All members of the group are structurally similar ionic inorganic compounds with the anion only changing by the number of hydrogen atoms to account for changes in charge due to increase in cation numbers.
Progression through each group sees an increase in cation number from one to three followed by a change in cation.
Cations are group 1 alkali metals sodium and potassium and group 2 alkaline earth metals calcium and magnesium. Na and K are in the +1 ionic state and Ca and Mg are in the +2 state. All cations are ubiquitous in natural waters and therefore the different cations are not considered to be of relevance for assessing the ecotoxicity of the aforementioned substances. The strategy is therefore designed to asses the toxicity of the phosphate ion.
All potassium and sodium orthophosphates are highly soluble and therefore represent a worst case in terms of bioavailability in natural waters. The magnesium and calcium orthophosphates are less soluble but are expected to dissociate to the ionic forms in water and therefore the toxicity results can be read across on the basis that all cations (Na+, K+, Ca2+ and Mg2+) are abundant in natural waters and are unlikely to contribute to toxicity.
The aforementioned substances differ in their acid or alkaline nature when dissolved in water, with pH values ranging from ca. pH3 to pH >14.These pH differences are not expected to be manifest in the natural environment, because of dilution and pH buffering by other compounds resulting in an ambient pH not dependent on the phosphate compound and therefore when taking in to account the substance to be tested; it was decided to test one which results in a solution of around pH 7 and therefore any pH-related effects will be discounted.
Data relevant for the derivation of PNECs:
PNECaqua (freshwater)
Use of short-term data only |
1000 |
Use of data on analogous substance (read-across) |
2 |
TOTAL |
2000 |
PNECaq freshwater= 100/2000 = 0.05
No long-term toxicity studies are available and therefore the PNEC is based on the lowest value from the short-term studies (100 mg/L), the assessment factor used takes the use of short-term data and read-across data into account. (AF for use of short-term data = 1000, AF for use of data on an analogue material = 2. Overall AF = 2000)
PNECaqua (marine)
Use of short-term data only |
10000 |
Use of data on analogous substance (read-across) |
2 |
TOTAL |
20000 |
PNECaq marine= 100/20000 =0.005mg/L
No reliable studies are available on marine species. The PNEC is therefore based on the short-term studies conducted on freshwater species.The assessment factor used takes the use of short-term data in freshwater species and read-across data into account. (AF for use of short-term freshwater data = 10000, AF for use of data on an analogue material = 2. Overall AF = 20000)
PNECintermittent release
Use of short-term data only |
100 |
Use of data on analogous substance (read-across) |
2 |
TOTAL |
200 |
PNECintermittent release= 100/200 =0.5 mg/L
The PNEC is based on the lowest value from the short-term studies (100 mg/L), the assessment factor used takes the use of read-across data into account. (AF for intermittent release = 100, AF for use of data on an analogue material = 2. Overall AF = 200)
PNECstp
· Assessment factors:
Standard AF for use with NOEC from ASRI study |
10 |
Use of data on analogous substance (read-across) [not relevant for dipotassium hydrogenorthophosphate] |
2 |
TOTAL |
20 |
· NOEC from ASRI study : 1000 mg/L
Calculated for read across substances and for tested substance (dipotassium hydrogenorthophosphate)
READ ACROSS:
PNECstp= 1000/20 =50 mg/L
DIPOTASSIUM HYDROGENORTHOPHOSPHATE:
PNECstp= 1000/10 =100 mg/L
The PNEC is based on the NOEC from the ASRI study. The assessment factor used takes the use of read-across data into account and uses the assessment factor appropriate for use of a NOEC value. (AF for use of NOEC = 10, AF for use of data on an analogue material = 2. Overall AF = 20)
PNECfreshwater sediment
No data is available for freshwater sediments. Na+, K+, Mg2+, Ca2+and PO43- ions are ubiquitous in the environment and are found naturally in soil, water and sediment. All are assimilated by species residing in the sediment, water or soil and are essential for maintaining a good chemical balance. It is therefore unlikely that inorganic phosphates of this nature would be toxic to sediment organisms and hence toxicity studies are scientifically unjustified.
PNECmarine sediment
No data is available for marine sediments. Na+, K+, Mg2+, Ca2+and PO43- ions are ubiquitous in the environment and are found naturally in soil, water and sediment. All are assimilated by species residing in the sediment, water or soil and are essential for maintaining a good chemical balance. It is therefore unlikely that inorganic phosphates of this nature would be toxic to sediment organisms and hence toxicity studies are scientifically unjustified.
PNECsoil
No data is available for soil macroorganisms. Na+, K+, Mg2+, Ca2+and PO43- ions are ubiquitous in the environment and are found naturally in soil, water and sediment. All are assimilated by species residing in the sediment, water or soil and are essential for maintaining a good chemical balance. Furthermore inorganic phosphate fertilizers (containing Na+, K+, Mg2+, Ca2+and PO43- ions) are often added to soils to improve soil quality. Given the extensive use of inorganic phosphates as soil fertilizers and the natural occurrence of the ions in the environment it is unlikely that inorganic phosphates of this nature would have a detrimental effect on soil macroorganisms and plants and hence toxicity studies are scientifically unjustified.
PNECoral
Inorganic phosphates are not considered to pose a risk of secondary poisoning as they are unlikely to bioaccumulate due to the fact that they are not lipophillic and will therefore not accumulate in fatty tissues. It not considered necessary to derive a PNEC to take into account the risk of secondary poisoning and no further testing is considered necessary.
Conclusion on classification
The following substances are not considered to pose a risk to the environment and as such are neither classified as harmful nor dangerous to the environment, in accordance with Regulation (EC) No. 1272/2008 (EU CLP):
Sodium and potassium orthophosphates:
Sodium dihydrogenorthophosphate
Disodium hydrogen phosphate
Trisodium orthophosphate
Potassium dihydrogenorthophosphate
Dipotsasium hydrogenorthophosphate
Tripotassium orthophosphate
Potassium pentahydrogen bis(phosphate)
Tripotassium trihydrogen diphosphate dihydrate.
Calcium and magnesium orthophosphates:
Calcium bis(dihydrogenorthophosphate)
Calcium hydrogen orthophosphate
Tricalcium bis(orthophosphate)
Tricalcium phosphate
Magnesium hydrogenorthophosphate
Trimagnesium bis(orthophosphate)
Magnesium bis(dihydrogenorthophosphate)
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