Registration Dossier
Registration Dossier
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EC number: 200-441-0 | CAS number: 59-67-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The Nicotinic acid toxicokinetic assessment is based on a weight of evidence approach. The toxicokinetic behavior of Nicotinic acid was previously reviewed by the European Commission Scientific Committee on Food, the EFSA Panel on Additives and Products or Substances used in Animal Feed, the US FDA and the UK Food Standards Agency Expert Group on Vitamins and Minerals. An OECD SIDS review concluded that nicotinic acid is essential for human and animal health and that based on the available information the substance does not present a hazard to human health.
Nicotinic acid is mainly taken up via the oral route, even though dermal and inhalation exposure may also lead to substance bioavailability. Once absorbed Nicotinic acid circulates in the plasma in the unbound form as both the acid and the amide. Animal studies have shown that Nicotinic acid rapidly disappears from the blood, with plasma half-life of ca. 1 hour. Main metabolites in humans are N-methylnicotinamide, N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide. Excretion is mainly via urine. The pattern of nicotinic acid products excreted after ingestion of the vitamin depends largely on the amount and form of Nicotinic acid ingested and on the Nicotinic acid status of the individual.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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