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Diss Factsheets
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EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
One in vitro study was available to assess the genotoxicity of Ethyl trifluoroacetate: an Ames test on the registered substance (Sire, 2007). The study was in compliance with the GLP and presented a good reliability (Kr. 1).
In a reverse gene mutation assay in bacteria, performed according to the OECD No.471 and EC No.B13/14 guidelines, strains TA1535, TA1537, TA100, TA98 and TA102 of S. typhimurium were exposed to ethyl trifluoroacetate (99.94%) diluted in DMSO in the presence and absence of mammalian metabolic activation (fraction of S9 from the liver of rats treated with Aroclor 1254). Since the test item was freely soluble and non-toxic in the preliminary test, the highest selected dose-level for the two independent main tests was 5000 µg/plate, according to the criteria specified in the international guidelines. Three replicates were realized per concentration of Ethyl trifluoroacetate (10, 100, 500, 1000, 2500 and 5000 µg/plate) in the main test.
Furthermore, method of direct incorporation and protocol with a preincubation step were tested. The positive controls induced the appropriate responses in the corresponding strains. Ethyl Trifluoroacetate was tested therefore up to limit concentration (5000 µg/plate) and no cytotoxicity was observed. No significant increase of the number of revertants was observed in any bacterial strains tested with Ethyl trifluoroacetate (at any concentrations). Under these test conditions, Ethyl Trifluoroacetate did not show mutagenic activity in the bacterial reverse mutation test with Salmonella typhimurium as there was no evidence of induced mutant colonies over background.
This study is considered as acceptable and satisfy the requirement for the mutagenicity endpoint.
Ethyl trifluoroacetate is not considered as mutagenic in bacteria.
Justification for selection of genetic toxicity endpoint
This key study is considered as acceptable and satisfy the requirement for the mutagenicity endpoint.
Short description of key information:
in vitro: Ames negative (Key study, reliability Kr. 1, OECD 471),
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Harmonized classification:
No harmonized classification is available for human health according to the Regulation (EC) No. 1272/2008 including the ATP2.
Self classification:
Based on the available data, Ethyl trifluoroacetate is not classified for genetic toxicity according to the criteria of the Annex I of the Regulation (EC) No 1272/2008 (CLP) and to the criteria of the Annex VI of the Directive 67/548/EEC.
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