Registration Dossier
Registration Dossier
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EC number: 200-939-8 | CAS number: 76-16-4
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Inhalation: cardiac sensitisation; dogs. NOAEC = 200000 ppm (1128931 mg/m3). No cardiac sensitisation was observed at the highest concentration tested. Reliability = 2.
Additional information
Male Beagle dogs received a control intravenous injection of epinephrine (0.008 mg/kg bw) and then subsequently were exposed to 200000 ppm (1128931 mg/m3) of the test substance. Approximately 5 minutes after the start of the exposure, the dogs were given another intravenous injection of epinephrine (0.008 mg/kg bw). No cardiac sensitisation was observed in any of the 12 tested dogs. The NOAEC was 200000 ppm based on the absence of cardiac sensitisation at this exposure level.
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