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Diss Factsheets
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EC number: 236-007-2 | CAS number: 13093-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro:
Bacterial reverse mutation assay:
Thompson (2013) performed an Ames (preliminary toxicity test, plate incorporation assay and preincubation method) test with S typhimurium strains TA1535, TA1537, TA98 and TA100 and Escherichia coli strain WP2uvrA in the presence and absence metabolic activation (10% S9 -mix).
Following test concentrations were applied in triplicate:
Preliminary toxicity test: 0, 0.15, 0.5, 1.5, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (cerium tetranitrate as active ingredient)
Mutation test - experiment 1:
15, 50, 150, 500, 1500, 5000 µg/plate (cerium tetranitrate as active ingredient)
Mutation test - experiment 2:
5, 15, 50, 150, 500, 1500, 5000 µg/plate (cerium tetranitrate as active ingredient)
Solvent control, negative control and positive controls were run in triplicate. Solvent, negative and positive controls were valid. The test item caused a visible reduction in the growth of the bacterial background lawns of TA100, TA1537 and WP2uvrA at 5000 µg/plate
in both the absence and presence of S9-mix and in both experiments. Weakened bacterial backgrond lawns were also noted for TA98 at 5000 µg/plate in the absence of S9 -mix employing pre-incubation methodology only. These results were not considered indicative of sufficient toxicity to prevent the test item being tested up to 5000 µg/plate. No precipitation was observed on the plates at any of the doses tested in the presence or absence of metabolic activation in both experiments.No significant increase in the frequency of revertant colonies was recorded for any bacterial strains, with any dose of the test item either with or without metabolic activation or exposure method. It was concluded, therefore, that cerium tetranitrate was not mutagenic under the conditions of the test.
Short description of key information:
Genetic toxicity in vitro:
In an Ames test according to OECD Guideline 471, EU Method B.13/14 and EPA OPPTS 870.5100 (Thompson, 2013), cerium tetranitrate proved to be negative for mutagenicity with and without metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
On the basis of the available information and according to the criteria of the DSD and CLP Regulation, cerium tetranitrate should not be classified for mutagenicity.
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