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EC number: 203-446-6 | CAS number: 106-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no deviations from standard test guidelines and no methodological deficiences, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-bromopropene
- EC Number:
- 203-446-6
- EC Name:
- 3-bromopropene
- Cas Number:
- 106-95-6
- Molecular formula:
- C3H5Br
- IUPAC Name:
- 3-bromoprop-1-ene
- Reference substance name:
- 1-bromoprop-2-ene
- IUPAC Name:
- 1-bromoprop-2-ene
- Details on test material:
- Lot 4-258-1
Colorless liquid
Container: one smoked glass flask
Purity: 99.5 %
Acidity (HBr) < 70 mg/kg
Storage conditions: at room temperature and protected from light
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Number and sex: one group of ten animals (five males and five females).
Age/weight: on the day of treatment, the animals were approximately six weeks old, and had a mean body weight ± standard deviation of 177±6 g for the males and 155±6 g for the females.
Acclimatization: at least five days before the beginning of the study.
Identification of the animals: the animals were identified individually by earmarks or earnotches.
During the acclimatization period and during the main test, the conditions in the animal room were as follow:
- temperature: 21±2°C
- relative humidity: 30 to 70%
- light/dark cycle: 12h/12h
- ventilation: about 12 cycles/hour of filtered, non-recycled air.
The temperature and relative humidity were recorded continuously and record retained.
The housing conditions (temperature, relative humidity and ventilation) were checked monthly.
The animals were housed in polycarbonate cages (48x27x20 cm). Each cage contained four to seven animals of the same sex during acclimatization period and five rats of the same sex during the treatment period. Each cage contained dustfree sawdust.
Bacteriological analysis of the sawdust and detection of possible contaminats (pesticides, heavy metals) are performed periodically.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Preliminary study: 2000 mg/kg bodyweight
Second step: 200 mg/kg bodyweight - No. of animals per sex per dose:
- Preliminary study: 5 males and 5 females
Second step: 5 males and 5 females - Control animals:
- no
Results and discussion
- Preliminary study:
- The result of the preliminary study indicated that the acute lethal oral dose of allyl bromide was less than 2000 mg/kg bodyweight
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occured during the observation period
- Clinical signs:
- other: Hypoactivity and piloerection wer observed on all animals up to day 4. First signs were observed 1 to 2 hours after treatment. Recovery was complete on day 5. .
- Gross pathology:
- Adhesions between the stomach, the spleen, the liver and the abdominal wall were observed in the animals of this group at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions, the oral LD50 of allyl bromide is between 200 and 2000 mg/kg in rats.
According to CLP regulation allyl bromide is classified as Toxic category III with the hazard statement H301 Toxic if swallowed.
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