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Diss Factsheets
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EC number: 203-767-1 | CAS number: 110-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- single dose followed by 14-day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to introduction of Good Laboratory Practices; data from a summary report; limited number of animals. Study was conducted by an internal Eastman Kodak Company method, developed prior to established guidelines. The results of this study are valid for classification insofar as the conditions of exposure are at least as stringent as modern guidelines.
Data source
Reference
- Reference Type:
- other: Eastman Kodak Company Summary Report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not specified
- Principles of method if other than guideline:
- Five groups of two rats each were administered single doses of 200, 400, 800, 1600, or 3200 mg/kg bw of the undiluted test substance by oral gavage and observed for a period of two weeks. Clinical observations and mortality were recorded during the study. Body weights were recorded prior to dosing and at termination of the observation period. Gross pathology was performed at study termination.
- GLP compliance:
- no
- Remarks:
- study conducted prior to GLPs
- Test type:
- other: Study conducted according to an internal Eastman Kodak Company laboratory method.
- Limit test:
- no
Test material
- Reference substance name:
- Heptan-2-one
- EC Number:
- 203-767-1
- EC Name:
- Heptan-2-one
- Cas Number:
- 110-43-0
- Molecular formula:
- C7H14O
- IUPAC Name:
- heptan-2-one
- Reference substance name:
- 606-024-00-3
- IUPAC Name:
- 606-024-00-3
- Reference substance name:
- methyl amyl ketone; methyl pentyl ketone; MAK; 1-methylhexanal; butylacetone
- IUPAC Name:
- methyl amyl ketone; methyl pentyl ketone; MAK; 1-methylhexanal; butylacetone
- Details on test material:
- -Identity (according to study report): methyl n-amyl ketone (MAK)
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Each animal received a single dose of the test material by oral gavage.
- Doses:
- 200, 400, 800, 1600, 3200 mg/kg bw
- No. of animals per sex per dose:
- 2 animals/dose (sex not specified)
- Control animals:
- no
- Details on study design:
- Two animals were assigned to each dose group (sex, age, and weights not provided). Rats were administered a single dose of the undiluted test material by oral gavage at dose levels of 200, 400, 800, 1600, or 3200 mg/kg bw. Rats were observed for a 14-day period for adverse clinical signs and mortality. Body weights were collected prior to dosing and at termination of the observation period. Gross pathology was performed at study termination.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 600 mg/kg bw
- Remarks on result:
- other: The highest dose level (3200 mg/kg bw) used in this study was higher than that used for a limit dose in present-day guideline studies.
- Mortality:
- Both animals at the highest dose level (3200 mg/kg bw) and one of two animals at 1600 mg/kg bw died 5 hours to 1 day after test substance administration. All remaining animals survived the 14-day observation period.
- Clinical signs:
- other: Clinical signs of toxicity reported in the study summary included weakness (slight to very weak), prostration, labored respiration, vasodilatation, and ataxia. Labored respiration occurred at oral doses of 800 mg/kg bw and above. No other clinical abnorm
- Gross pathology:
- No findings were noted in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- In an acute oral toxicity test, the oral LD50 was approximately 1600 mg/kg bw for rats (sex not specified) administered a single dose of undiluted methyl n-amyl ketone. Abnormal clinical signs reported in the study included weakness, prostration, labored respiration, vasodilatation, and ataxia. Deaths in the 1600 and 3200 mg/kg bw dose groups occurred between 5 hours and 1 day of dose administration. All surviving animals gained weight and there were no adverse effects observed at necropsy.
- Executive summary:
In an acute oral toxicity study, five groups containing two rats each were administered a single dose of undiluted methyl n-amyl ketone by oral gavage at dose levels of 200, 400, 800, 1600, or 3200 mg/kg bw. The rats were observed for mortality and adverse clinical signs for a period of 14 days. Both rats in the highest dose group (3200 mg/kg bw) and one rat in the 1600 mg/kg bw dose group died 5 hours to 1 day post dose. No other mortality was noted during the study. The oral LD50 in rats administered methyl n-amyl ketone is approximately 1600 mg/kg bw. Clinical signs of toxicity reported in the study summary included weakness (slight to very weak), prostration, labored respiration, vasodilatation, and ataxia. No other clinical abnormalities were noted throughout the study. All surviving rats gained weight over the 14-day observation period and no gross changes were observed at necropsy. Based on the results of this study, methyl n-amyl ketone is harmful by the oral route. Ingestion of large amounts may cause CNS depression (fatigue, dizziness and possible loss of concentration, with collapse, coma and death in cases of severe over-exposure).
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