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EC number: 219-460-0 | CAS number: 2439-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Ministry of Health and Welfare, Japan(1997a): Toxicity Testing Reports of Environmental chemicals, vol.5, 583-594, "Combined Repeat Dose and Reproductive/Developmental|Toxicity Screening Test of 2-(Dimethylamino)ethyl acrylate by Oral Administration in Rats"
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: Purity 99.9%, NIPPON SHOKUBAI CO.,LTD., Lot No. 5P07
TS-Freetext:
SOURCE: NIPPON SHOKUBAI CO.,LTD. Lot No. 5P07
PURITY: 99.9 wt%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- Exposure period: males, 43 day; females, from 14 day before mating to day 3 of lactation
Premating exposure period (males): 14 day
Premating exposure period (females): 14 day
Duration of test: males; 43 day, females; from 14 day before mating to day 4 of lactation- 54 day - Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0(Vehicle), 4, 20, 100 mg/kg/day
Basis:
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 100 mg/kg bw/day
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
For reproduction toxicity
NOAELs: = 100 mg/kg/day for males
= 100 mg/kg/day for females
= 100 mg/kg/day for F1 offsprings
2-(dimethylamino)ethyl acrylate had no effects on reproductive parameters such as the mating index, the fertility index, number of corpora lutea or implantations, the implantation index, the gestation index, the delivery index, gestation length, parturition or maternal behavior. On examination of neonates, these were no significant differences in number of offspring or live offspring, the sex ratio, the live birth index, the viability index or body weight. No abnormal findings ascribable to the compound were found for external features, clinical signs or necroscopy of the offspring.
- Female:
At 100 mg/kg/day, 2 females out of 12 died.
- By the observation, a decrease in the absolute thymus weight was observed.
- By the necroscopy examination, similar changes as males were observed.
- By the histopathological examination, similar changes as males were observed.
At 20 mg/kg/day and 4 mg/kg/day, no effects were observed.
Female:
Dose [mg/kg/day] Note 0 4 20 100 100
(dead)
-------------------- ------ --- --- ---- --- -----
No. of animals 12 12 12 10 2
Findings in Lymph node
(pancreatico-duodenal)
-Hyperplasia, plasma + # # # 7/7 #
cell
Finding in forestomach
-Hyperplasia, mucosa ++ 0 0 0 10** 1
-Inflammatory cell ++ 0 0 0 10** 1
inifiltration
-Ulcer ++ 0 0 0 9** 1
--------------------------------------------------------
Reproductive parameters:
- Dose [mg/kg/day] 0 4 20 100
------------------------------------------------------
-Number of pairs examined 12 12 12 11#
-Number of pairs with 12 12 12 10
successful mating
-Mating index (%) 100 100 100 100
-Number of pregnant females 11 11 11 9
-Fertility index (%) 91.7 91.7 91.7 90.0
-Pairing days until mating 2.0 2.1 2.0 3.6
-Number of estrous stages
without mating 0 0 0 0
--------------------------------------------------------
Mating index (%) = (No. of pairs with successful mating /
No. of pairs examined) x 100
Fertility index (%) = (No. of pregnant animals / No. of
pairs with successful mating) x 100
Developmental parameters:
Dose [mg/kg/day] 0 4 20 100
----------------------------------------------------
-Number of females examined 11 11 11 8
-Live birth index (%) 98.6 99.4 98.7 95.1
-Number of pups delivered 16.2 15.4 13.8 15.8
-Number of live pups on day0 15.9 15.3 13.6 14.9
- Sex ratio (male/female) 0.9 70.9 11.1 40.89
-Viability index on day 4(%) 90.9 99.4 98.8 87.5
-Number of live pups on day4 14.4 15.2 13.5 13.4
-Body weight gain of pups [g]
day 0 to 4 male 4.3 4.3 4.2 3.8
female 4.2 4.3 4.2 3.7
----------------------------------------------------
Live birth index (%) = (No. of live pups on day 0 / No. of
pups delivered) x 100
Viabitity index (%) = (No. of live pups on day 4 / No. of
pups on day 0) x 100
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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