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EC number: 231-308-5 | CAS number: 7491-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 freshwater invertebrates = 6.6 mg /L. This information is based on read across to the sodium salt of the corresponding substance.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.6 mg/L
Additional information
Data are available for the corresponding sodium salt of the substance, docusate sodium. These data are used for read-across to the substance registered.
For the data endpoint “Short-term toxicity to aquatic invertebrates” 2 experimental studies are available: Both are Klimisch 2.
The study from Elementis (Scholz 1993) was classified as Klimisch 2 study. In this study the acute toxicity of formulated product - which contains 64.2% Docusate Sodium, ~ 24% water and ~ 10% ethanol- to Daphnia magna was determined in a static GLP compliant test. The test was performed according to guideline EG 84/449 which is similar to EU method C.2 and OECD 202. The test was started with a control and nominal 2.5, 3.5, 5, 7, 10, 14, 20, 28 and 40 mg formulated product/L corresponding to 0 (control), 1.61, 2.25, 3.21, 4.49, 6.42, 8.99, 12.84, 17.98 and 25.68 mg Docusate Sodium/L. For each test concentration and the control, 4 replicates with 5 daphnids each were set up in 10 mL vessels. The test was performed in darkness. Dose-verification analysis was not performed and hence, the concentrations were reported as nominal concentrations. After 48 hours of exposure, 5, 0, 10, 35, 35, 55, 50, 71, 85 and 100 % of the daphnids were immobilized at 0 (control), 1.61, 2.25, 3.21, 4.49, 6.42, 8.99, 12.84, 17.98 and 25.68 mg Docusate Sodium/L. The corresponding 48 h EC50 value is 6.6 mg Docusate Sodium/L (95% C.I. 5.3 to 8.2 mg Docusate Sodium/L).
The study from Cytec (Goodrich and Lech 1985) was classified as Klimisch 2 study. In this study the acute toxicity of the test substance - which contains 99% Docusate Sodium - to Daphnia magna was determined in a static test. GLP compliance was not stated. The test was performed similar to EEC C.2 and OECD 202. The test was started with a control and nominal 5, 10, 20, 40 and 80 mg test substance /L corresponding to 0 (control), 4.95, 9.9, 19.8, 39.6 and 79.2 mg Docusate Sodium/L. For each test concentration and the control, 4 replicates with 5 daphnids each were set up in 100 mL vessels filled with 80 mL test solution. The test was performed in a 16:8 hour light dark cycle. Dose-verification analysis was not performed and hence, the concentrations were reported as nominal concentrations. After 48 hours of exposure, 0, 0, 0, 5, 60 and 100 % of the daphnids were immobilized at 0 (control), 4.95, 9.9, 19.8, 39.6 and 79.2 mg Docusate Sodium/L. The corresponding 48 h EC50 value is 34.9 mg Docusate Sodium/L. This study is considered to be acceptable for the risk assessment.
The EC50 values of the two Klimisch 2 studies from Scholz (1993) and Goodrich and Lech (1985) were 6.6 and 34.9 mg Docusate Sodium/L, respectively. The evaluation which of the EC50 values is more reliable and relevant for the risk assessment will be made based on (1) the test design, (2) the test material used, and (3) if there is further evidence from disregarded studies with lower Klimisch scores.
(1): Both guideline compliant studies were of comparable quality and hence no decision which study is more relevant could be made based on the test design.
(2): The higher purity of the test material (99% vs. 64%) in the study from Cytec (Goodrich and Lech 1985) when compared to Elementis (Scholz 1993) could indicate that the study from Cytec (Goodrich and Lech 1985) is more relevant. On the other hand, the further constituents of the test material used by Elementis (Scholz 1993) were water (~24%) and ethanol (~10%), both not toxic at 100 mg/L. Therefore, these constituents are not expected to have an effect on the toxicity of the test material.
As worst case the most protective value, the lowest EC50, i. e., the EC50 of 6.6 mg Docusate Sodium/L from Elementis (Scholz 1993) was selected for the further risk assessment for aquatic invertebrates and the CSA.
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