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Diss Factsheets
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EC number: 203-250-0 | CAS number: 104-90-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1976
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material: 5-ethyl-2-methyl-pyridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young rats
- Weight at study initiation: 200 - 300 g
- Fasting period before study: 24 hours
- Housing: Common cage
- Diet: Ad libitum
- Water: Ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED:
- 4.0 mL/kg bw - Doses:
- 250, 500, 640, 800, 1000, 2000, 4000 mg/kg bw.
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily observations
- Necropsy of survivors performed: No
- Other examinations performed: None.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 250 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 250 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 710 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 470 - 1 040
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 710 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 470 - 1 040
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 710 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 470 - 1 040
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- <= 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD100
- Effect level:
- <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- On day one following dosing mortality was observed for all animals (5/5) of the high dose group (4000 mg/kg bw), three animals of the 2000 mg/kg bw and one animal each of the 1000, 800 and 640 mg/kg bw dose group. On day two of the observation period mortality was observed for two animals of the 2000 mg/kg bw and three animals of the 1000 mg/kg bw dose group. On day four one animal each of the 800 and 500 mg/kg bw dose groups were found dead. Following the 14 day observation period all animals (5/5) of the low dose group (250 mg/kg bw), 4/5 of the 500 and 600 mg/kg bw dose groups, 1/5 of the 800 mg/kg bw dose group and 0/5 of the 2000 and 4000 mg/kg bw dose groups survived.
- Clinical signs:
- other: Male animals dosed at 250 mg/kg bw and 500 mg/kg bw were languid with unkempt coats and nasal hemorrhage. Nasal hemorrhage and lethargy accompanied unkempt coats were observed in male animals at 640 mg/kg bw and 800 mg/kg bw. Male survivors appeared norma
- Gross pathology:
- Not determined.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study groups of fasted young albino rats (5 male/5 female per dose group) were given a single oral dose (gavage) of 250, 500, 640, 800, 1000, 2000, 4000 mg/kg bw and observed daily for 14 days. The obtained oral LD50 for males and females was 710 mg/kg bw (95% C.I. 470 – 1040 mg/kg bw). The LD0 obtained was 250 mg/kg bw and the LD100 was 2000 mg/kg bw.
- Executive summary:
A study similar or equivalent to EU Method B.1 and OECD Guideline 401 (Acute toxicity oral) was carried out. Groups of fasted young albino rats (5 male/5 female) were given a single oral dose (gavage) of 250, 500, 640, 800, 1000, 2000, 4000 mg/kg bw. The animals were observed daily for 14 days thereafter. The obtained oral LD50 for males and females was 710 mg/kg bw (95% C.I. 470 – 1040 mg/kg bw). The LD0 obtained was 250 mg/kg bw and the LD100 was 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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