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Diss Factsheets
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EC number: 214-770-2 | CAS number: 1193-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study acceptable for assessment, basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- GLP compliance:
- yes
- Type of study:
- other: LLNA; proceeding not described in detail
Test material
- Reference substance name:
- 4,6-dichloropyrimidine
- EC Number:
- 214-770-2
- EC Name:
- 4,6-dichloropyrimidine
- Cas Number:
- 1193-21-1
- Molecular formula:
- C4H2Cl2N2
- IUPAC Name:
- 4,6-dichloropyrimidine
Constituent 1
In vivo test system
Test animals
- Species:
- other: no data
- Strain:
- other: no data
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- Vehicle only
0.1 % w/v
0.3 % w/v
1.0 % w/v - No. of animals per dose:
- no data
Results and discussion
Any other information on results incl. tables
Concentration of test material CPM/Lymph Test/Control Ratio
node (x10 -2)
Vehicle only (DMSO) 1.48 --
0.1 % w/v 2.06 1.4
Vehicle only (DMSO) 2.45 --
0.3 % w/v 10.47 4.3
1.0 % w/v 16.93 6.9
Additional concentrations of 0.3 and 1 % w/v of the TS were dosed with a corresponding control group to confirm any sensitization response.
The incorporation of radioactive material is given as counts per minute/Lymph node x 10 -2 and the Stimulation Index (SI) as Test/Control Ratio.
For the higher concentrations (0,3 % and 1,0 %) in DMSO an SI exceeding the value of 3 was obtained (4,3 and 6,9; respectively).
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Only a very short summary of the study is available. No details on study design or performance are reported. Based on the data given the TS should
be regarded as a potential skin sensitizer at concentrations of 0.3 % and 1.0 %.
Therefore the TS is classified as Xi, R 43 (may cause sensitization by skin contact)
Although it is likely that the design of this study does not fulfill the requirements of OECD 429 ("Skin sensititisation: Local Lymph Node Assay") and only a very short summary of the report is available instead of a complete report, the study may be regarded as valid with restrictions (Klimisch 2, basic data given) and used for assessment if 4,6-dichloropyrimidine is classifled as Xi; R43 (may cause sensitization by skin contact) for precautionary reasons as the results of study are not surprising or unexpeded. No new study should be performed due to animal welfare.
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