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EC number: 288-511-7 | CAS number: 85736-99-8 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 53228.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10.October.2011 - 19.01.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of signature July 2011
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 22.3 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 4.3
- Details on results:
- Please see section Remarks on results including tables and figures.
- Conclusions:
- The water solubility of the test item was determined to be 22.3 mg/L at 20 °C.
- Executive summary:
The water solubility was determined according to OECD 105 and Regulation (EC) No. 440/2008 method A.6 using the shake flask method. About 102-104 mg test item were weighed into 100 mL flasks according to the estimated solubility based on the Preliminary Test. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C for 24 hours, 48 hours and 72 hours and re-equilibrated at 20 °C for not less than 24 hours. The contents of the flasks were filtered through two 0.2 tm filters and the pH of each solution was measured. Total organic carbon (TOC) was used to analyze the samples. The water solubility of the test item was determined to be 22.3 mg/L at 20 °C.
Reference
The total carbon, inorganic carbon and total organic carbon concentrations of the samples and check standard are shown in the following table:
Table 2
Solution |
Total Organic Carbon (mg/L) |
Check standard 50 mg/L |
49.37 |
Sample blank |
1.359 |
Sample lA |
14.31 |
Sample 1B |
14.20 |
Sample 2A |
305.70 |
Sample 2B |
314.50 |
Sample 3A |
12.88 |
Sample 3B |
13.09 |
The concentration (g/L) of the main component in the test item in the sample solutions is shown in the following table:
Table 3
Sample Number |
Time Shaken at 30 °C (hours) |
Time Equilibrated at |
concentration of Main Component (g/L) |
Solution pH |
1 |
24 |
24 |
2.35 x 10 -2 |
4.3 |
2 |
48 |
24 |
0.563 |
4.3 |
3 |
72 |
24 |
2.12 x 10-2 |
4.3 |
Mean concentration of main component: 2.23 x 10-2g/L at 20.0 ± 0.5 °C
Range: 2.12 x 10 -2 to 2.35 x 10-2g/L
TOC was used to analyze the samples. The preliminary result did not include the subtraction of a sample blank, as was the case for the definitive test, as no sample blank was performed. This will therefore represent a worst case scenario.
Centrifugation was not used in the clean up procedure of the saturated samples of the definitive test as this had been shown to be ineffective during clean up of the preliminary test sample. The definitive result can be considered a worst case scenario as TOC analysis is not substance specific so any other carbon containing component from the test item would be measured as well.
Description of key information
The water solubility of the test item was determined to be 22.3 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 22.3 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined according to OECD 105 and Regulation (EC) No. 440/2008 method A.6 using the shake flask method. About 102-104 mg test item were weighed into 100 mL flasks according to the estimated solubility based on the Preliminary Test. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C for 24 hours, 48 hours and 72 hours and re-equilibrated at 20 °C for not less than 24 hours. The contents of the flasks were filtered through two 0.2 tm filters and the pH of each solution was measured. Total organic carbon (TOC) was used to analyze the samples. The water solubility of the test item was determined to be 22.3 mg/L at 20 °C.
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