Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-370-1 | CAS number: 2425-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October to November 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: missing test substance characterisation, reduced observation period of 7 days; no information on clinical observations and body weights
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: HAZARDOUS SUBSTANCES, Part 191, Section 11, FDA, Washington 1965
- GLP compliance:
- no
- Test type:
- other: Rabbits were exposed to test substance for 24 hours on intact and scarified skin. The treatment was followed by a 7-day observation period. Skin reactions, behaviour, general condition, food and water consumption and body weight gain were recorded.
- Limit test:
- no
Test material
- Reference substance name:
- 2-hexyldecan-1-ol
- EC Number:
- 219-370-1
- EC Name:
- 2-hexyldecan-1-ol
- Cas Number:
- 2425-77-6
- Molecular formula:
- C16H34O
- IUPAC Name:
- 2-hexyldecan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Hexyl-decanol
no more details mentioned
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: laboratory breed
- Age at study initiation: not mentioned
- Weight at study initiation: 2.3 - 2.8 kg
- Housing: single housing in stainless steel cages
- Diet: Altromin 2023, ad libitum, supplied by Altromin GmbH, Lage, Germany
- Water: Drinking water ad libitum
- Acclimation period: not mentioned
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 60 ± 3
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 15 x 16 cm on the back of the animals, 3 animals per sex were treated on intact skin, 3 animals per sex were treated on abraded skin
- % coverage: 10
- Type of wrap if used: not wrapped
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water (30°C)
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.3-2.8 ml and 4.6-5.6 ml
- Constant volume or concentration used: no - Duration of exposure:
- 24 hours
- Doses:
- 1 and 2 mL/kg bw
- No. of animals per sex per dose:
- 6 (3 with intact, 3 with scarified skin)
- Control animals:
- other: control group (3 animals per sex per intact/scarified skin) exposed with 2 ml 1% aqueous methylhydroxy ethyl Cellulose Gel 300 P
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: skin effects (erythema, edema) were recorded 5, 15, 30 min, 1, 2, 4, 24, 48, 72, 96, 120, 144 and 168 hours after removal of the test substance. General behaviour, food and water intake and body weight were recorded daily.
- Necropsy of survivors performed: no
- Other examinations performed: none
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Mortality:
- no mortality occured during the course of the study
- Clinical signs:
- other: only slight skin irritation noted
- Gross pathology:
- not performed
- Other findings:
- Necrosis and rhagades were not observed, growth of hair was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2-Hexyldecan-1-ol is practically nontoxic after dermal application to rabbits. No mortality occured after derman application of up to 2 ml/kg bw test substnce on intact or scarified skin.
- Executive summary:
2-Hexyldecan-1-ol is practically nontoxic after dermal application to rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Kuigi ECHA veebilehe paljud osad on sinu keeles olemas, on see leht osaliselt inglise keeles. Lisateave ECHA mitmekeelsuse kohta.
Tere tulemast Euroopa Kemikaaliameti (ECHA) veebilehele! Internet Explorer 7 (ja varasemad versioonid) ei toeta täielikult seda veebilehte. Uuendage oma Internet Exploreri versiooni.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Lisateave küpsiste kohta.