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EC number: 601-147-9 | CAS number: 111988-49-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 Jun - 6 Jul 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity: Fixed Dose Procedure)
- Version / remarks:
- adopted 2017
- Deviations:
- yes
- Remarks:
- Some deviations to the current guideline exist: male and females were tested, all animals were tested simultaneously, and it was not stated how many percent of the skin were covered, females exceeded the recommended age.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin
- EC Number:
- 601-147-9
- Cas Number:
- 111988-49-9
- Molecular formula:
- C10H9ClN4S
- IUPAC Name:
- 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Paderborn, Germany
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 10 weeks (males) and 14 - 16 weeks (females)
- Weight at study initiation: 245 - 256 g (males) and 208 - 218 g (females)
- Fasting period before study: not indicated
- Housing: during testing period individually in polycarbonate cages type IIA, during acclimatization in groups in polycarbonate cages type III (<180g five animals >180g max. three animals per cage), both with low-dust wood granules type S 8/15 (Ssniff, Spezialdiäten GmbH, Soest/Westphalia, Germany)
- Historical data: available
- Diet: Altromin® 1324 Diet for Rats and Mice (Altromin GmbH and Co. KG, Lage, Germany), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 7 days
- Microbiological status when known: no pathogens detected
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 40 - 70
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.9% NaCl solution
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 3.5 x 4.5 cm (males) and 4.0 x 4.0 cm (females)
- % coverage: not indicated
- Type of wrap if used: The paste of the test substance and 0.9% NaCl solution was formed on a piece of aluminum foil. It was then applied with the foil and fixed in place with an occlusive dressing (fermoflex®).
REMOVAL OF TEST SUBSTANCE
- Washing: soap and water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 2000 mg/kg bw
- Constant volume or concentration used: no
- For solids, paste formed: yes
VEHICLE: NaCl solution
- Amount applied : 1.0 mL per g test substance
- Concentration: 0.9% - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Appearance and behavior was recorded several times on the day of treatment, and at least once a day thereafter. The body weights of the rats were recorded on day 1 before administration and then weekly.
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes, appearance, behavior, reactivity, motility, reflexes, gait, paralysis, spasms, tremors etc., respiratory frequency, heart rate, pallor, posture and gastrointestinal functions - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- No mortality occurred until the end of the observation period. Please refer to Attachment 1.
- Clinical signs:
- other: No clinical signs and no local skin reactions were observed.
- Gross pathology:
- No gross pathologic changes were observed in animals killed at the end of the study period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 for male and female rats was >2000 mg/kg bwt. The test substance caused no systemic toxicity to Wistar rats following acute dermal application. The study is considered valid.
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